Despite advancements in treatment protocols, cancer is one of the leading cause of deaths
worldwide. Therefore, there is a need to identify newer and personalized therapeutic targets …

The application of mass spectrometry imaging (MSI) to explore the responses of cancer cell
spheroids (CCS) after treatment of exogenous molecules has attracted growing attention …

Triclosan (TCS), an antimicrobial compound, is known to have potential endocrine-
disruptive properties, but the underlying toxic mechanisms at the metabolic level are not well …

As more and more studies have shown that lipid molecules play an important role in the
whole biology, in-depth analysis of lipid structure has become particularly important in …

Lipid droplets (LDs), which are the hubs of lipid metabolism, play a critical role in
maintaining cellular energy homeostasis. The construction of advanced photosensitizers …

There is a close relationship between the biological functions of lipids and their structures,
and various isomers greatly increases the complexity of lipid structures. The C= C bond …

Accurate lipid quantification is essential to revealing their roles in physiological and
pathological processes. However, difficulties in the structural resolution of lipid isomers …

Camptothecin is a pentacyclic natural alkaloid that inhibits the hTop1 enzyme involved in
DNA transcription and cancer cell growth. Camptothecin structure pitfalls prompted us to …

Cancer cell spheroids (CCS) are a valuable three-dimensional cell model in cancer studies
because they could replicate numerous characteristics of solid tumors. Increasing …

Lipids and metabolites are small biological molecules that act major roles in cellular
functions. Multicellular tumor spheroids (MCTS) are a highly beneficial three-dimensional …