Treatment of neurodegenerative diseases or other central nervous system (CNS) disorders
has always been a significant challenge. The nature of the blood-brain barrier (BBB) limits …

Now a day's intranasal (in) drug delivery is emerging as a reliable method to bypass the
blood–brain barrier (BBB) and deliver a wide range of therapeutic agents including both …

The blood-brain barrier (BBB) is a highly specialized structural and biochemical barrier that
regulates the entry of blood-borne molecules into brain, and preserves ionic homeostasis …

The primary aim of this study was to investigate the potential use of chitosan nanoparticles
as a delivery system to enhance the brain targeting efficiency of bromocriptine (BRC) …

P-glycoprotein (P-gp), a transmembrane permeability glycoprotein, is a member of ATP
binding cassette (ABC) super family that functions specifically as a carrier mediated primary …

Nine proteins of the ABC superfamily (P-glycoprotein, 7 MRPs and BCRP) are involved in
multidrug transport. Being localised at the surface of endothelial or epithelial cells, they …

In oral bioavailability studies, evaluation of the absorption and transport of drugs and food
components across the intestinal barrier is crucial. Advances in the field of organ-on-a-chip …

Bromocriptine Mesylate (BRM) acts as a dopamine receptor agonist along with antioxidant
effect and is utilized in the treatment of Parkinson's disease (PD). Glutathione (GSH) is a …

Interaction with the dopaminergic system in the central nervous system is either
therapeutically intended or it is a side effect. In both cases, dopamine-receptor agonists …

Neurodegenerative diseases (NDDs) significantly contribute to morbidity and mortality
worldwide. The suboptimal effect of currently used therapeutic approaches administered via …