The MYC proto-oncogene is frequently activated in human cancers through a variety of
mechanisms. Its deregulated expression, unconstrained by inactivation of key checkpoints …

The PGC-1 family of regulated coactivators, consisting of PGC-1α, PGC-1β and PRC, plays
a central role in a regulatory network governing the transcriptional control of mitochondrial …

Driver mutations in oncogenic pathways, rewiring of cellular metabolism and altered ROS
homoeostasis are intimately connected hallmarks of cancer. Electrons derived from different …

Although cancers have altered glucose metabolism, termed the Warburg effect, which
describes the increased uptake and conversion of glucose to lactate by cancer cells under …

Mitochondria contain their own genetic system and undergo a unique mode of cytoplasmic
inheritance. Each organelle has multiple copies of a covalently closed circular DNA genome …

Gene regulatory factors encoded by the nuclear genome are essential for mitochondrial
biogenesis and function. Some of these factors act exclusively within the mitochondria to …

For more than a decade, numerous studies have suggested that the c-Myc oncogenic
protein is likely to broadly influence the composition of the transcriptome. However, the …

The role of the myc gene family in the biology of normal and cancer cells has been
intensively studied since the early 1980s. myc genes, responding to diverse external and …

The transcription factor Myc is induced by mitogenic signals and regulates downstream
cellular responses. If overexpressed, Myc promotes malignant transformation. Myc …

In addition to oxidative phosphorylation (OXPHOS), mitochondria perform other functions
such as heme biosynthesis and oxygen sensing and mediate calcium homeostasis, cell …