Cell-to-cell variation and heterogeneity are fundamental and intrinsic characteristics of stem
cell populations, but these differences are masked when bulk cells are used for omic …

Despite being a relatively recent technological development, single-cell transcriptional
analysis through high-throughput sequencing has already been used in hundreds of fruitful …

Recent advances in single-cell transcriptomics are ideally placed to unravel intratumoral
heterogeneity and selective resistance of cancer stem cell (SC) subpopulations to …

Since its establishment in 2009, single-cell RNA sequencing (RNA-seq) has been a major
driver behind progress in biomedical research. In developmental biology and stem cell …

Activation of complex molecular programs in specific cell lineages governs mammalian
heart development, from a primordial linear tube to a four-chamber organ. To characterize …

An underlying question for virtually all single-cell RNA sequencing experiments is how to
allocate the limited sequencing budget: deep sequencing of a few cells or shallow …

INTRODUCTION The measurement of specific proteins and transcripts in individual cells is
critical for understanding the role of cellular diversity in development, health, and disease …

Single-cell RNA-sequencing (scRNA-Seq) is a compelling approach to directly and
simultaneously measure cellular composition and state, which can otherwise only be …

Background Cell type-specific ribosome-pulldown has become an increasingly popular
method for analysis of gene expression. It allows for expression analysis from intact tissues …

Single-cell RNA-sequencing (scRNA-seq) is revolutionizing our understanding of the
genomic, transcriptomic and epigenomic landscapes of cells within organs. The mammalian …