Peptic ulcer disease

A Lanas, FKL Chan - The Lancet, 2017 - thelancet.com
The rapidly declining prevalence of Helicobacter pylori infection and widespread use of
potent anti-secretory drugs means peptic ulcer disease has become substantially less …

The Toronto consensus for the treatment of Helicobacter pylori infection in adults

CA Fallone, N Chiba, SV van Zanten, L Fischbach… - Gastroenterology, 2016 - Elsevier
Background & Aims Helicobacter pylori infection is increasingly difficult to treat. The purpose
of these consensus statements is to provide a review of the literature and specific, updated …

The appropriate use of proton pump inhibitors (PPIs): need for a reappraisal

V Savarino, P Dulbecco, N de Bortoli… - European journal of …, 2017 - Elsevier
The advent of powerful acid-suppressive drugs, such as proton pump inhibitors (PPIs), has
revolutionized the management of acid-related diseases and has minimized the role of …

Non-variceal upper gastrointestinal bleeding

A Lanas, JM Dumonceau, RH Hunt… - Nature reviews Disease …, 2018 - nature.com
Non-variceal upper gastrointestinal bleeding (NVUGIB) is bleeding that develops in the
oesophagus, stomach or proximal duodenum. Peptic ulcers, caused by Helicobacter pylori …

Proton pump inhibitors: use and misuse in the clinical setting

V Savarino, E Marabotto, P Zentilin… - Expert review of …, 2018 - Taylor & Francis
Introduction: The introduction of proton pump inhibitors (PPIs) into clinical practice has
greatly improved our therapeutic approach to acid-related diseases for their efficacy and …

Psychological stress increases risk for peptic ulcer, regardless of Helicobacter pylori infection or use of nonsteroidal anti-inflammatory drugs

S Levenstein, S Rosenstock, RK Jacobsen… - Clinical …, 2015 - Elsevier
Background & Aims There is controversy over whether psychological stress contributes to
development of peptic ulcers. We collected data on features of life stress and ulcer risk …

Epidemiology and risk factors for upper gastrointestinal bleeding

T Tielleman, D Bujanda, B Cryer - Gastrointestinal Endoscopy …, 2015 - giendo.theclinics.com
Upper gastrointestinal bleeding (UGIB) is defined as hemorrhage that involves the mouth to
the duodenum proximal to the ligament of Treitz. Common causes of UGIB include peptic …

Peptic ulcer disease

E Sverdén, L Agréus, JM Dunn, J Lagergren - Bmj, 2019 - bmj.com
Peptic ulcer disease presents with gastrointestinal symptoms similar to dyspepsia and can
be difficult to distinguish clinically. It can have potentially serious complications such as …

“Stress” is 80 years old: From Hans Selye original paper in 1936 to recent advances in GI ulceration

S Szabo, M Yoshida, J Filakovszky… - Current pharmaceutical …, 2017 - ingentaconnect.com
The first scientific publication on 'general adaption syndrome', or as we know today 'biologic
stress' has been published in Nature in 1936 by the 29-year old Hans Selye. His results in …

bacteria and pathogenesis of disease in the upper gastrointestinal tract – beyond the era of Helicobacter pylori

MM Walker, NJ Talley - Alimentary pharmacology & …, 2014 - Wiley Online Library
Background Study of the upper gastrointestinal microbiome has shown that other bacteria
besides Helicobacter pylori flourish despite the hostile environment. Whilst H. pylori is the …