Transition fibers (TFs) regulate cilia gating and make the primary cilium a distinct functional
entity. However, molecular insights into the biogenesis of a functional cilia gate remain …

Duplication of the centrosomes is a tightly regulated process. Abnormal centrosome
numbers can impair cell division and cause changes in how cells migrate. Duplicated …

Biogenesis of the primary cilium, a cellular organelle mediating various signaling pathways,
is generally coordinated with cell cycle exit/re-entry. Although the dynamic cell cycle …

Joubert syndrome (JS) is a ciliopathy associated with mutations in numerous genes
encoding cilia components. TALPID3 encoded by KIAA0856 in man (2700049A03Rik in …

Cilia are microtubule-based appendages present on almost all vertebrate cell types where
they mediate a myriad of cellular processes critical for development and homeostasis. In …

The chicken has been a particularly useful model for the study of craniofacial development
and disease for over a century due to their relatively large size, accessibility, and …

The primary cilium is an antenna-like projection from the plasma membrane that serves as a
sensor of the extracellular environment and a crucial signaling hub. Primary cilia are …

Cellular processes are highly dependent on a dynamic proteome that undergoes structural
and functional rearrangements to allow swift conversion between different cellular states. By …

Alternating Hemiplegia of Childhood (AHC) is a devastating autosomal dominant disorder
caused by ATP1A3 mutations, resulting in severe hemiplegia and dystonia spells, ataxia …

Ciliopathies are human disorders caused by dysfunction of primary cilia, ubiquitous
microtubule-based organelles involved in signal transduction. Cilia are anchored inside the …