The molecular structure and function of sorting nexin 10 in skeletal disorders, cancers, and other pathological conditions
SNX10 is a member of the phox homology domain‐containing family of phosphoinositide‐
binding proteins. Intracellularly, SNX10 localizes to endosomes where it mediates …
binding proteins. Intracellularly, SNX10 localizes to endosomes where it mediates …
Osteopetrosis associated with PLEKHM1 and SNX10 genes, both involved in osteoclast vesicular trafficking
Y Huybrechts, W Van Hul - Bone, 2022 - Elsevier
The clinical and radiological variability seen in different forms of osteopetrosis, all due to
impaired osteoclastic bone resorption, reflect many causal genes. Both defective …
impaired osteoclastic bone resorption, reflect many causal genes. Both defective …
[HTML][HTML] Sorting Nexin 10 as a key regulator of membrane trafficking in bone-resorbing osteoclasts: lessons learned from osteopetrosis
A Elson, M Stein, G Rabie, M Barnea-Zohar… - Frontiers in cell and …, 2021 - frontiersin.org
Bone homeostasis is a complex, multi-step process, which is based primarily on a tightly
orchestrated interplay between bone formation and bone resorption that is executed by …
orchestrated interplay between bone formation and bone resorption that is executed by …
Autosomal Dominant Osteopetrosis (ADO) Caused by a Missense Variant in the TCIRG1 Gene
W Jodeh, AJ Katz, M Hart, SJ Warden… - The Journal of …, 2024 - academic.oup.com
Context Autosomal dominant osteopetrosis (ADO) is a rare genetic disorder resulting from
impaired osteoclastic bone resorption. Clinical manifestations frequently include fractures …
impaired osteoclastic bone resorption. Clinical manifestations frequently include fractures …
[HTML][HTML] Accumulation of fat not responsible for femoral head necrosis, revealed by single-cell RNA sequencing: A preliminary study
Y Wang, D Li, H Chen, Z Li, B Feng, X Weng - Biomolecules, 2023 - mdpi.com
The etiology of osteonecrosis of the femoral head (ONFH) is not yet fully understood.
However, ONFH is a common disease with high morbidity, and approximately one-third of …
However, ONFH is a common disease with high morbidity, and approximately one-third of …
SNX10 regulates the clearance of mitochondrial proteins and mitochondrial bioenergetics
L Trachsel-Moncho, BJ Mathai, C Veroni, A Lapao… - bioRxiv, 2024 - biorxiv.org
We here show that SNX10 localizes to endocytic compartments in a PtdIns3P-dependent
manner and that mutations in the PX domain associated with autosomal recessive …
manner and that mutations in the PX domain associated with autosomal recessive …
[HTML][HTML] Case report: Gene mutations and clinical characteristics of four patients with osteopetrosis
Y Chen, L Zhou, X Guan, X Wen, J Yu, Y Dou - Frontiers in Pediatrics, 2023 - frontiersin.org
Osteopetrosis is characterized by increased bone density caused by decreased osteoclasts
or dysfunction of their differentiation and absorption properties, usually caused by biallelic …
or dysfunction of their differentiation and absorption properties, usually caused by biallelic …
Identification of Key Amino Acid Residues Involved in the Localization of Sorting Nexin 10 and Induction of Vacuole Formation
B Xiao, N Liu, L Hou, M Jiang, D Yao - Biochemistry (Moscow), 2021 - Springer
Abstract Sorting nexin 10 (SNX10) induces formation of vacuoles participating in the
endosome morphogenesis in mammalian cells, but the key amino acids involved in this …
endosome morphogenesis in mammalian cells, but the key amino acids involved in this …