Improving head and neck cancer therapies by immunomodulation of the tumour microenvironment
AT Ruffin, H Li, L Vujanovic, DP Zandberg… - Nature Reviews …, 2023 - nature.com
Targeted immunotherapy has improved patient survival in head and neck squamous cell
carcinoma (HNSCC), but less than 20% of patients produce a durable response to these …
carcinoma (HNSCC), but less than 20% of patients produce a durable response to these …
NK cells and solid tumors: therapeutic potential and persisting obstacles
L Tong, C Jiménez-Cortegana, AHM Tay, S Wickström… - Molecular cancer, 2022 - Springer
Natural killer (NK) cells, which are innate lymphocytes endowed with potent cytotoxic
activity, have recently attracted attention as potential anticancer therapeutics. While NK cells …
activity, have recently attracted attention as potential anticancer therapeutics. While NK cells …
B cells, plasma cells and antibody repertoires in the tumour microenvironment
GV Sharonov, EO Serebrovskaya… - Nature Reviews …, 2020 - nature.com
Recent data show that B cells and plasma cells located in tumours or in tumour-draining
lymph nodes can have important roles in shaping antitumour immune responses. In tumour …
lymph nodes can have important roles in shaping antitumour immune responses. In tumour …
Pembrolizumab plus cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma: an open-label, multi-arm, non-randomised …
AG Sacco, R Chen, FP Worden, DJL Wong… - The Lancet …, 2021 - thelancet.com
Summary Background Pembrolizumab (PD-1 inhibitor) and cetuximab (EGFR inhibitor) are
active as single agents and in combination with cytotoxic chemotherapy for recurrent or …
active as single agents and in combination with cytotoxic chemotherapy for recurrent or …
The latest battles between EGFR monoclonal antibodies and resistant tumor cells
WQ Cai, LS Zeng, LF Wang, YY Wang, JT Cheng… - Frontiers in …, 2020 - frontiersin.org
Epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor involved in
homeostatic regulation of normal cells and carcinogenesis of epithelial malignancies. With …
homeostatic regulation of normal cells and carcinogenesis of epithelial malignancies. With …
NK cell-mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy
Natural killer (NK) cells play a major role in cancer immunotherapies that involve tumor-
antigen targeting by monoclonal antibodies (mAbs). NK cells express a variety of activating …
antigen targeting by monoclonal antibodies (mAbs). NK cells express a variety of activating …
Single‐cell landscape and clinical outcomes of infiltrating B cells in colorectal cancer
J Xia, Z Xie, G Niu, Z Lu, Z Wang, Y Xing, J Ren… - …, 2023 - Wiley Online Library
B cells constitute a major component of infiltrating immune cells in colorectal cancer (CRC).
However, the characteristics of B cells and their clinical significance remain unclear. In this …
However, the characteristics of B cells and their clinical significance remain unclear. In this …
Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
C Bokemeyer, I Bondarenko, A Makhson… - Journal of clinical …, 2009 - ascopubs.org
Purpose This randomized study assessed whether the best overall response rate (ORR) of
cetuximab combined with oxaliplatin, leucovorin, and fluorouracil (FOLFOX-4) was superior …
cetuximab combined with oxaliplatin, leucovorin, and fluorouracil (FOLFOX-4) was superior …
Understanding resistance to EGFR inhibitors—impact on future treatment strategies
DL Wheeler, EF Dunn, PM Harari - Nature reviews Clinical oncology, 2010 - nature.com
EGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis.
Following ligand binding, EGFR stimulates downstream cell signaling cascades that …
Following ligand binding, EGFR stimulates downstream cell signaling cascades that …
Antibody‐dependent cell cytotoxicity: immunotherapy strategies enhancing effector NK cells
MC Ochoa, L Minute, I Rodriguez… - Immunology and cell …, 2017 - Wiley Online Library
Antibody‐dependent cellular cytotoxicity (ADCC) is a set of mechanisms that target cells
coated with IgG antibodies of the proper subclasses (IgG1 in the human) to be the prey of …
coated with IgG antibodies of the proper subclasses (IgG1 in the human) to be the prey of …