Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

The process of regeneration serves to heal injury by replacing missing cells. Understanding
regeneration can help us replace cell populations lost during disease, such as the insulin …

Understanding the mechanisms of cellular differentiation is challenging because
differentiation is initiated by signaling pathways that drive temporally dynamic processes …

Information remains scarce on human development compared to animal models. Here, we
reconstructed human fetal pancreatic differentiation using cell surface markers. We …

Aims/hypothesis While pancreatic beta cells have been shown to originate from endocrine
progenitors in ductal regions, it remains unclear precisely where beta cells emerge from and …

Inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), statins, which are used to
prevent cardiovascular diseases, are associated with a modest increase in the risk of new …

Aims/hypothesis Lineage conversion of non-beta cells into insulin-producing cells has been
proposed as a therapy for the cure of diabetes. Glucagon-like peptide-1 (GLP-1) and its …

Differentiation of human pluripotent stem cells (hPSCs) into subtype-specific neurons holds
substantial potential for disease modeling in vitro. For successful differentiation, a detailed …

Aims/hypothesis Glucagon-expressing pancreatic alpha cells have attracted much attention
for their plasticity to transdifferentiate into insulin-producing beta cells; however, it remains …

Genetically modified mice have been widely used in the field of β-cell research. However,
analysis of results gathered using genetically modified organisms should be interpreted …