Solid tumours are often first diagnosed by palpation, suggesting that the tumour is more rigid
than its surrounding environment. Paradoxically, individual cancer cells appear to be softer …

Background: For more than a century, diagnostic pathologists have used morphologic
abnormalities of the nucleus as essential diagnostic features to distinguish benign from …

Aberrations in nuclear size and shape are commonly used to identify cancerous tissue.
However, it remains unclear whether the disturbed nuclear structure directly contributes to …

Studies of chromosome and genome biology often focus on condensed chromatin in the
form of chromosomes and neglect the non-dividing cells. Even when interphase nuclei are …

Cells generate and sense mechanical forces that trigger biochemical signals to elicit cellular
responses that control cell fate changes. Mechanical forces also physically distort …

ATR responds to mechanical stress at the nuclear envelope and mediates envelope-
associated repair of aberrant topological DNA states. By combining microscopy, electron …

Neutrophil nuclear morphology has historically been used in haematology for neutrophil
identification and characterisation, but its exact role in neutrophil function has remained …

Alterations in nuclear shape are present in human diseases and ageing. A compromised
nuclear lamina is molecularly interlinked to altered chromatin functions and genomic …

Background Key hepatic molecules linking gut dysbiosis and hepatocarcinogenesis remain
largely unknown. Gut-derived gut microbiota contains pathogen-associated molecular …

Cancer cells' ability to migrate through constricting pores in the tissue matrix is limited by
nuclear stiffness. MT1-MMP contributes to metastasis by widening matrix pores, facilitating …