Applications of single-cell RNA sequencing in drug discovery and development
B Van de Sande, JS Lee, E Mutasa-Gottgens… - Nature Reviews Drug …, 2023 - nature.com
Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …
together with associated computational tools and the growing availability of public data …
Statistical and machine learning methods for spatially resolved transcriptomics data analysis
The recent advancement in spatial transcriptomics technology has enabled multiplexed
profiling of cellular transcriptomes and spatial locations. As the capacity and efficiency of the …
profiling of cellular transcriptomes and spatial locations. As the capacity and efficiency of the …
TISCH2: expanded datasets and new tools for single-cell transcriptome analyses of the tumor microenvironment
Abstract The Tumor Immune Single Cell Hub 2 (TISCH2) is a resource of single-cell RNA-
seq (scRNA-seq) data from human and mouse tumors, which enables comprehensive …
seq (scRNA-seq) data from human and mouse tumors, which enables comprehensive …
Multiplexed imaging mass cytometry of the chemokine milieus in melanoma characterizes features of the response to immunotherapy
Intratumoral immune cells are crucial for tumor control and antitumor responses during
immunotherapy. Immune cell trafficking into tumors is mediated by binding of specific …
immunotherapy. Immune cell trafficking into tumors is mediated by binding of specific …
Integrated analysis of single-cell and bulk RNA sequencing data reveals a pan-cancer stemness signature predicting immunotherapy response
Background Although immune checkpoint inhibitor (ICI) is regarded as a breakthrough in
cancer therapy, only a limited fraction of patients benefit from it. Cancer stemness can be the …
cancer therapy, only a limited fraction of patients benefit from it. Cancer stemness can be the …
A novel anoikis-related gene signature predicts prognosis in patients with head and neck squamous cell carcinoma and reveals immune infiltration
Background: Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive
disease with a poor prognosis for advanced tumors. Anoikis play a key role in cancer …
disease with a poor prognosis for advanced tumors. Anoikis play a key role in cancer …
CellCall: integrating paired ligand–receptor and transcription factor activities for cell–cell communication
Y Zhang, T Liu, X Hu, M Wang, J Wang… - Nucleic acids …, 2021 - academic.oup.com
With the dramatic development of single-cell RNA sequencing (scRNA-seq) technologies,
the systematic decoding of cell-cell communication has received great research interest. To …
the systematic decoding of cell-cell communication has received great research interest. To …
[HTML][HTML] Expanding PROTACtable genome universe of E3 ligases
Proteolysis-targeting chimera (PROTAC) and other targeted protein degradation (TPD)
molecules that induce degradation by the ubiquitin-proteasome system (UPS) offer new …
molecules that induce degradation by the ubiquitin-proteasome system (UPS) offer new …
Therapeutically increasing MHC-I expression potentiates immune checkpoint blockade
Immune checkpoint blockade (ICB) therapy revolutionized cancer treatment, but many
patients with impaired MHC-I expression remain refractory. Here, we combined FACS-based …
patients with impaired MHC-I expression remain refractory. Here, we combined FACS-based …
C1q+ macrophages: passengers or drivers of cancer progression
M Revel, C Sautès-Fridman, WH Fridman… - Trends in Cancer, 2022 - cell.com
The omics era made possible the quest for efficient markers for cancer progression and
revealed that macrophage populations are much more complex than just the M1/M2 …
revealed that macrophage populations are much more complex than just the M1/M2 …