Background: Endothelial cells in the tumor microenvironment play an important role in the
development of kidney renal clear cell carcinoma (KIRC). We wanted to further identify the …

Background Protein disulfide isomerase A3 (PDIA3) is a member of the protein disulfide
isomerase (PDI) family that participates in protein folding through its protein disulfide …

Single-cell multi-omics (scMulti-omics) has brought transformative insights into immuno-
oncology, demonstrating success in describing novel immune subsets and defining …

Background Baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, member of the
inhibitor of apoptosis (IAP), is a multitasking protein and among the top 100 deregulated …

Single-cell sequencing opens a new era for the investigation of tumor immune
microenvironments (TIME). However, at single-cell resolution, a pan-cancer analysis that …

Drugs that kill tumors through multiple mechanisms have the potential for broad clinical
benefits. Here, we first developed an in silico multiomics approach (BipotentR) to find cancer …

Immune checkpoint blockade (ICB) therapy provides remarkable clinical benefits for multiple
cancer types. Much work is currently being conducted to investigate the mechanisms of ICB …

Disulfidptosis is a newly-identified non-programmed cell death mode with tight associations
with glucose metabolism. Elevated glycolysis is an important metabolic feature of tumor …

Background: Necroptosis has been identified recently as a newly recognized programmed
cell death that has an impact on tumor progression and prognosis, although the necroptosis …

It is a challenge to efficiently integrate and present the tremendous amounts of single-cell
data generated from multiple tissues of various species. Here, we create a new database …