The use of psychoactive drugs is a wide spread behaviour in human societies. The
systematic use of a drug requires the establishment of different drug use-associated …

Environmental stimuli are powerful mediators of craving and relapse in substance‐abuse
disorders. This review examined how animal models have been used to investigate the …

Cocaine abuse and addiction remain great challenges on the public health agendas in the
US and the world. Increasingly sophisticated perspectives on addiction to cocaine and other …

There is compelling evidence that sex and gender have crucial roles in excessive alcohol
(ethanol) consumption. Here, we review some of the data from the perspective of brain …

Epidemiological studies consistently find correlations between nicotine and alcohol use, yet
the neural mechanisms underlying their interaction remain largely unknown. Nicotine and …

Abstract The 5-HT 6 receptor (5-HT 6 R) is almost exclusively expressed in the brain and
has emerged as a promising target for cognitive disorders, including Alzheimer's disease. In …

Substance use disorder, and particularly psychostimulant use disorder, has considerable
socioeconomic burden globally. The psychostimulants include several chemical classes …

5-hydroxytryptamine6 receptor (5-HT6R) antagonists have shown efficacy in animal models
for cognitive impairment in multiple cognitive domains relevant for schizophrenia …

A current survey and synthesis of the most important findings in our understanding of the
neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series …

Depression is nowadays a major contributor to global burden of disease. The most
commonly prescribed drugs influence monoaminergic pathways, mainly concentrating on …