Cells with stem‐like properties, tumorigenic potential, and treatment‐resistant phenotypes
have been identified in many human malignancies. Based on the properties they share with …

Cancer cell dormancy is a common feature of human tumors and represents a major clinical
barrier to the long-term efficacy of anticancer therapies. Dormant cancer cells, either in …

Drug discovery is a multidisciplinary and multivariate optimization endeavor. As such, in
silico screening tools have gained considerable importance to archive, analyze and exploit …

Ionizing radiation (IR) has been shown to play a crucial role in the treatment of glioblastoma
(GBM; grade IV) and non-small-cell lung cancer (NSCLC). Nevertheless, recent studies …

Quiescence is a reversible cell-cycle arrest which allows cancer stem-like cells to evade
killing following therapies. Here, we show that proliferating glioblastoma stem-like cells …

Cancer stem cells are a subpopulation of tumor cells that proliferate, self-renew and produce
more differentiated tumoral cells building-up the tumor. Responsible for the sustained …

Glioblastoma is the most aggressive and deadly brain cancer. There is growing interest to
develop drugs that specifically target to glioblastoma tumor-initiating cells (TICs). However …

Cellular quiescence (G0) is a sleep-like cellular state that allows cells to maintain the ability
to re-enter and exit the proliferative cycle. Quiescent cancer cells are considered a …

There is growing interest in developing drugs that specifically target glioblastoma tumor-
initiating cells (TICs). Current cell culture methods, however, cannot cost-effectively produce …

The brain of adult mammals, including humans, contains neural stem cells (NSCs) located
within specific niches of which the ventricular-subventricular zone (V-SVZ) is the largest one …