Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Fibrosis, defined by the excess deposition of structural and matricellular proteins in the
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …

Cisplatin is a widely used chemotherapy drug; however, it induces both acute and chronic
kidney diseases (CKD) in patients with cancer. The pathogenesis of cisplatin-induced CKD …

Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Background: Renal infiltration of inflammatory cells including macrophages is a crucial event
in kidney fibrogenesis. However, how macrophage regulates fibroblast activation in the …

The extracellular matrix (ECM) is a complex three-dimensional network of proteins
surrounding cells, forming a niche that controls cell adhesion, proliferation, migration and …

Rationale: Cisplatin, a potent chemotherapeutic drug, induces side effects in normal tissues
including the kidney. To reduce the side effects, repeated low-dose cisplatin (RLDC) is …

Organ fibrosis can occur in virtually all major organs with relentlessly progressive and
irreversible progress, ultimately resulting in organ dysfunction and potentially death …