The inflammatory pathogenesis of colorectal cancer
M Schmitt, FR Greten - Nature Reviews Immunology, 2021 - nature.com
The mutational landscape of colorectal cancer (CRC) does not enable predictions to be
made about the survival of patients or their response to therapy. Instead, studying the …
made about the survival of patients or their response to therapy. Instead, studying the …
Molecular mechanisms of colon cancer progression and metastasis: recent insights and advancements
Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause
of cancer-related mortality rates worldwide. Although modern research was able to shed …
of cancer-related mortality rates worldwide. Although modern research was able to shed …
[HTML][HTML] The molecular characteristics of colorectal cancer: Implications for diagnosis and therapy
Colorectal cancer (CRC) results from the progressive accumulation of multiple genetic and
epigenetic aberrations within cells. The progression from colorectal adenoma to carcinoma …
epigenetic aberrations within cells. The progression from colorectal adenoma to carcinoma …
Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells
U Testa, E Pelosi, G Castelli - Medical Sciences, 2018 - mdpi.com
Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …
Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF-Mutated Colorectal Cancer
Purpose BRAF V600E mutation is seen in 5% to 8% of patients with metastatic colorectal
cancer (CRC) and is associated with poor prognosis. Vemurafenib, an oral BRAF V600 …
cancer (CRC) and is associated with poor prognosis. Vemurafenib, an oral BRAF V600 …
The molecular hallmarks of the serrated pathway in colorectal cancer
Colorectal cancer (CRC) is a leading cause of cancer death worldwide. It includes different
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …
Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value
Background Colon cancer (CC) pathological staging fails to accurately predict recurrence,
and to date, no gene expression signature has proven reliable for prognosis stratification in …
and to date, no gene expression signature has proven reliable for prognosis stratification in …
Genetics and genetic biomarkers in sporadic colorectal cancer
JM Carethers, BH Jung - Gastroenterology, 2015 - Elsevier
Sporadic colorectal cancer (CRC) is a somatic genetic disease in which pathogenesis is
influenced by the local colonic environment and the patient's genetic background …
influenced by the local colonic environment and the patient's genetic background …
Epigenetic and genetic features of 24 colon cancer cell lines
D Ahmed, PW Eide, IA Eilertsen, SA Danielsen… - Oncogenesis, 2013 - nature.com
Cell lines are invaluable biomedical research tools, and recent literature has emphasized
the importance of genotype authentication and characterization. In the present study, 24 out …
the importance of genotype authentication and characterization. In the present study, 24 out …
[HTML][HTML] Colorectal cancer carcinogenesis: a review of mechanisms
Colorectal cancer (CRC) is the second most common cancer in women and the third most
common in men globally. CRC arises from one or a combination of chromosomal instability …
common in men globally. CRC arises from one or a combination of chromosomal instability …