Peroxisomes are unique among the organelles of the endomembrane system. Unlike other
organelles that derive most if not all of their proteins from the ER (endoplasmic reticulum) …

ATP-binding cassette (ABC) transporters belong to one of the largest families of membrane
proteins, and are present in almost all living organisms from eubacteria to mammals. They …

Peroxisomes are conserved organelles of eukaryotic cells with important roles in cellular
metabolism, human health, redox homeostasis, as well as intracellular metabolite transfer …

ATP-binding cassette (ABC) transporters constitute one of the largest superfamilies of
conserved proteins from bacteria to mammals. In humans, three members of this family are …

Peroxisomes are a class of structurally and functionally related organelles present in almost
all eukaryotic cells. The importance of peroxisomes for human life is highlighted by severe …

Peroxisomes are a dynamic compartment in almost all eukaryotic cells and have diverse
metabolic roles in response to environmental changes and cellular demands. The …

Tail-anchored (TA) proteins are anchored into cellular membranes by a single
transmembrane domain (TMD) close to the C terminus. Although the targeting of TA proteins …

Tail-anchored proteins contain a single transmembrane domain (TMD) followed by a short C-
terminal domain extending into the organellar lumen. Tail-anchored proteins are thought to …

Genetic and proteomic approaches have led to the identification of 32 proteins, collectively
called peroxins, which are required for the biogenesis of peroxisomes. Some are …

In contrast to the molecular mechanisms underlying import of peroxisomal matrix proteins,
those involving the transport of membrane proteins remain rather elusive. At present, two …