[HTML][HTML] Prevalence of multidrug-resistance and bla VIM and bla IMP genes among gram-negative clinical isolates in tertiary care hospital, Kathmandu, Nepal
M Ansari, SC Aryal, G Rai, KR Rai… - Iranian journal of …, 2021 - ncbi.nlm.nih.gov
Materials and Methods: A total of 1,151 clinical samples were collected from the patients
visiting Annapurna Neurological Institute and Allied Science and Annapurna Research …
visiting Annapurna Neurological Institute and Allied Science and Annapurna Research …
Metallo-beta-lactamases: mechanisms, treatment challenges, and future prospects
ABSTRACT Introduction Metallo-beta-lactamases (MBLs) are responsible for resistance to
almost all beta-lactam antibiotics. Found predominantly in Gram-negative bacteria, they …
almost all beta-lactam antibiotics. Found predominantly in Gram-negative bacteria, they …
[HTML][HTML] Development and application of a pragmatic algorithm to guide definitive carbapenemase testing to identify carbapenemase-producing Pseudomonas …
CM Gill, TE Asempa, DP Nicolau - Antibiotics, 2020 - mdpi.com
A minimum inhibitory concentration (MIC) derived algorithm, predictive of carbapenemase
production, was developed using a challenge set (n= 92) of Pseudomonas aeruginosa (PA) …
production, was developed using a challenge set (n= 92) of Pseudomonas aeruginosa (PA) …
[HTML][HTML] Carbapenem resistance in Enterobacterales from agricultural, environmental and clinical origins: South Africa in a global context
T Ramkisson, D Rip - AIMS microbiology, 2023 - ncbi.nlm.nih.gov
Carbapenem agents are regarded as last-resort antibiotics, however, bacterial resistance
towards carbapenems has been reported in both clinical and agricultural settings worldwide …
towards carbapenems has been reported in both clinical and agricultural settings worldwide …
Rapid Detection and Characterization of Carbapenemases in Enterobacterales with a New Modified Carbapenem Inactivation Method, mCIMplus
M Petit, F Caméléna, A Cointe, T Poncin… - Journal of Clinical …, 2020 - Am Soc Microbiol
The worldwide emergence and spread of antimicrobial resistance in Gram-negative bacteria
are severely limiting therapeutic options and thus constitute a major public health threat. The …
are severely limiting therapeutic options and thus constitute a major public health threat. The …
[HTML][HTML] The carbapenem inoculum effect provides insight into the molecular mechanisms underlying carbapenem resistance in Enterobacterales
Carbapenem-resistant Enterobacterales (CRE) are important pathogens that can develop
resistance via multiple molecular mechanisms, including hydrolysis or reduced antibiotic …
resistance via multiple molecular mechanisms, including hydrolysis or reduced antibiotic …
[HTML][HTML] Rapid Detection of blaKPC in Carbapenem-Resistant Enterobacterales Based on CRISPR/Cas13a
M Liang, B Xiao, L Chen, X Huang, J Li, Z Kuang… - Current …, 2023 - Springer
Klebsiella pneumoniae carbapenemase (KPC) is a crucial enzyme that causes carbapenem
resistance in Enterobacterales, and infections by these" superbugs" are extremely …
resistance in Enterobacterales, and infections by these" superbugs" are extremely …
Multicenter evaluation of the BD Phoenix CPO detect test for detection and classification of carbapenemase-producing organisms in clinical isolates
V Whitley, S Kircher, T Gill, JA Hindler… - Journal of Clinical …, 2020 - Am Soc Microbiol
Limited treatment options contribute to high morbidity/mortality rates with carbapenem-
resistant, Gram-negative bacterial infections. New approaches for carbapenemase …
resistant, Gram-negative bacterial infections. New approaches for carbapenemase …
[HTML][HTML] Multicenter evaluation of Xpert Carba-R assay for detection and identification of the carbapenemase genes in rectal swabs and clinical isolates
X Jin, H Zhang, S Wu, X Qin, P Jia, FC Tenover… - The Journal of Molecular …, 2021 - Elsevier
Rapid detection of carbapenemase-producing organisms is clinically desirable for hospital
infection control and antibiotic stewardship. In this multicenter study, the Xpert Carba-R …
infection control and antibiotic stewardship. In this multicenter study, the Xpert Carba-R …
[HTML][HTML] Liquid Chromatography-Tandem Mass Spectrometry Analysis Demonstrates a Decrease in Porins and Increase in CMY-2 β-Lactamases in Escherichia coli …
DE Foudraine, CNM Aarents, AA Wattel… - Frontiers in …, 2022 - frontiersin.org
While Extended-Spectrum β-Lactamases (ESBL) and AmpC β-lactamases barely degrade
carbapenem antibiotics, they are able to bind carbapenems and prevent them from …
carbapenem antibiotics, they are able to bind carbapenems and prevent them from …