[HTML][HTML] Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy
XL Fan, Y Zhang, X Li, QL Fu - Cellular and molecular life sciences, 2020 - Springer
Mesenchymal stem cells (MSCs) have been extensively investigated for the treatment of
various diseases. The therapeutic potential of MSCs is attributed to complex cellular and …
various diseases. The therapeutic potential of MSCs is attributed to complex cellular and …
[HTML][HTML] The therapeutic potential of mesenchymal stromal cells for regenerative medicine: current knowledge and future understandings
M Merimi, R El-Majzoub, L Lagneaux… - Frontiers in Cell and …, 2021 - frontiersin.org
In recent decades, research on the therapeutic potential of progenitor cells has advanced
considerably. Among progenitor cells, mesenchymal stromal cells (MSCs) have attracted …
considerably. Among progenitor cells, mesenchymal stromal cells (MSCs) have attracted …
[HTML][HTML] Hypoxia-elicited mesenchymal stem cell-derived exosomes facilitates cardiac repair through miR-125b-mediated prevention of cell death in myocardial …
Exosomes (Exo) secreted from hypoxia-conditioned bone marrow mesenchymal stem cells
(BM-MSCs) were found to be protective for ischemic disease. However, the role of exosomal …
(BM-MSCs) were found to be protective for ischemic disease. However, the role of exosomal …
[HTML][HTML] Comparative study of extracellular vesicles derived from mesenchymal stem cells and brain endothelial cells attenuating blood–brain barrier permeability via …
Y Li, B Liu, T Zhao, X Quan, Y Han, Y Cheng… - Journal of …, 2023 - Springer
Background Blood–brain barrier (BBB) disruption is a major adverse event after ischemic
stroke (IS). Caveolin-1 (Cav-1), a scaffolding protein, played multiple roles in BBB …
stroke (IS). Caveolin-1 (Cav-1), a scaffolding protein, played multiple roles in BBB …
[HTML][HTML] Multicellular crosstalk between exosomes and the neurovascular unit after cerebral ischemia. Therapeutic implications
Restorative strategies after stroke are focused on the remodeling of cerebral endothelial
cells and brain parenchymal cells. The latter, ie, neurons, neural precursor cells and glial …
cells and brain parenchymal cells. The latter, ie, neurons, neural precursor cells and glial …
[HTML][HTML] Engineered exosomes: desirable target-tracking characteristics for cerebrovascular and neurodegenerative disease therapies
As extracellular vesicles secreted by cells, exosomes are intercellular signalosomes for cell
communication and pharmacological effectors. Because of their special properties, including …
communication and pharmacological effectors. Because of their special properties, including …
Application of mesenchymal stem cell-derived extracellular vesicles for stroke: biodistribution and microRNA study
GJ Moon, JH Sung, DH Kim, EH Kim, YH Cho… - Translational stroke …, 2019 - Springer
Mesenchymal stem cells (MSCs) exert their therapeutic capability through a variety of
bioactive substances, including trophic factors, microRNAs, and extracellular vesicles (EVs) …
bioactive substances, including trophic factors, microRNAs, and extracellular vesicles (EVs) …
Mesenchymal stem cell-derived extracellular vesicle-based therapies protect against coupled degeneration of the central nervous and vascular systems in stroke
Stem cell-based treatments have been suggested as promising candidates for stroke.
Recently, mesenchymal stem cells (MSCs) have been reported as potential therapeutics for …
Recently, mesenchymal stem cells (MSCs) have been reported as potential therapeutics for …
[HTML][HTML] Extracellular vesicle-based therapy for COVID-19: Promises, challenges and future prospects
The COVID-19 pandemic has become a serious concern and has negatively impacted
public health and the economy. It primarily targets the lungs, causing acute respiratory …
public health and the economy. It primarily targets the lungs, causing acute respiratory …
In vivo monitoring and assessment of exogenous mesenchymal stem cell-derived exosomes in mice with ischemic stroke by molecular imaging
R Xu, Y Bai, S Min, X Xu, T Tang… - International Journal of …, 2020 - Taylor & Francis
Purpose Mesenchymal stem cell-derived exosomes (MSC-exos) are considered an
important restorative treatment for ischemic stroke. However, the migration ability and …
important restorative treatment for ischemic stroke. However, the migration ability and …