Amongst heterocyclic compounds, quinoline is an advantaged scaffold that appears as a
significant assembly motif for the development of new drug entities. Quinoline and its …

Bronchodilators are central in the treatment of of airways disorders. They are the mainstay of
the current management of chronic obstructive pulmonary disease (COPD) and are critical in …

Despite the passionate debate over the use of β2‐adrenoceptor agonists in the treatment of
airway disorders, these agents are still central in the symptomatic management of asthma …

Background Indacaterol is a novel, inhaled, once-daily ultra long-acting β 2-agonist (ultra-
LABA) for the treatment of COPD. This study investigated the effect of indacaterol on …

Clinical trials have recently demonstrated that using a budesonide/formoterol combination
inhaler as regular maintenance treatment twice daily but also as a rescue therapy for …

Background Indacaterol is an inhaled, long-acting β 2-agonist providing 24-h
bronchodilation with once-daily dosing in patients with COPD. Methods Subjects with …

For optimal efficacy, an inhaler should deliver doses consistently and be easy for patients to
use with minimal instruction. The delivery characteristics, patients' correct use, and …

Heterocyclic N‐oxides are prevalent in numerous natural products with broad applications in
pharmaceuticals, agrochemicals, material sciences, and asymmetric synthesis. Owing to …

Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow
limitation and debilitating symptoms. For patients with moderate-to-severe COPD, long …

β2-Adrenoceptor agonists evoke rapid bronchodilatation and are the mainstay of the
treatment of asthma symptoms worldwide. The mechanism of action of this class of …