Sustained 24-hour efficacy of once daily indacaterol (300 μg) in patients with chronic obstructive pulmonary disease: a randomized, crossover study

C LaForce, J Aumann, L de Teresa Parreño… - Pulmonary …, 2011 - Elsevier
PURPOSE: Indacaterol is a novel, once daily, inhaled ultra-long-acting β2-agonist for the
treatment of chronic obstructive pulmonary disease (COPD). Here we compared the 24-h …

Characterization of the bronchodilatory dose response to indacaterol in patients with chronic obstructive pulmonary disease using model-based approaches

D Renard, M Looby, B Kramer, D Lawrence… - Respiratory …, 2011 - Springer
Background Indacaterol is a once-daily long-acting inhaled β 2-agonist indicated for
maintenance treatment of moderate-to-severe chronic obstructive pulmonary disease …

Chirality of β2-agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis

Č Ružena, V Jindra, H Renáta - Open Chemistry, 2020 - degruyter.com
Abstract β2-Agonists (β2-adrenergic agonists, bronchodilatants, and sympathomimetic
drugs) are a group of drugs that are mainly used in asthma and obstructive pulmonary …

Efficacy and safety of indacaterol 150 and 300 µg in chronic obstructive pulmonary disease patients from six Asian areas including Japan: A 12‐week, placebo …

M Kinoshita, SH Lee, LWEN HANG, M Ichinose… - …, 2012 - Wiley Online Library
Background and objective: The efficacy and safety of indacaterol, a novel inhaled once daily
ultra long‐acting β2‐agonist was evaluated in COPD patients in six Asian countries/areas …

Study of the emitted dose after two separate inhalations at different inhalation flow rates and volumes and an assessment of aerodynamic characteristics of indacaterol …

M Abadelah, H Chrystyn, G Bagherisadeghi… - AAPS …, 2018 - Springer
Onbrez Breezhaler® is a low-resistance capsule-based device that was developed to
deliver indacaterol maleate. The study was designed to investigate the effects of both …

Ultra long-acting β-agonists in chronic obstructive pulmonary disease

RM Burkes, RJ Panos - Journal of Experimental Pharmacology, 2020 - Taylor & Francis
Introduction Inhaled β-agonists have been foundational medications for maintenance COPD
management for decades. Through activation of cyclic adenosine monophosphate …

Getting to the heart of asthma: Can “β blockers” be useful to treat asthma?

RA Bond, D Spina, S Parra, CP Page - Pharmacology & therapeutics, 2007 - Elsevier
β2-adrenoceptor agonists are the mainstay for the acute symptomatic treatment of asthma
and provide effective bronchoprotection to a wide range of bronchoconstrictor agents …

Long-acting β2-adrenoceptor agonists: a smart choice for asthma?

BJ Lipworth - Trends in pharmacological sciences, 2007 - cell.com
An endogenous defect in β 2-adrenoceptors that results in impaired relaxation of airway
smooth muscle was originally proposed as a putative underlying cause of the asthmatic …

Indacaterol: a comprehensive review

A Rossi, G Polese - International Journal of Chronic Obstructive …, 2013 - Taylor & Francis
At present there is no cure for chronic obstructive pulmonary disease (COPD). However,
some nonpharmacologic treatments, such as rehabilitation and lung volume reduction …

Mono-and combination therapy of long-acting bronchodilators and inhaled corticosteroids in advanced COPD

JA Ohar, JF Donohue - Seminars in respiratory and critical care …, 2010 - thieme-connect.com
Beta-2 adrenergic agonists are sympathomimetic agents that stimulate bronchodilation by
activation of adenyl cyclase to produce cyclic 3′ 5′ adenosine monophosphate (AMP) …