[HTML][HTML] Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer
Background Limitless self-renewal is one of the hallmarks of cancer and is attained by
telomere maintenance, essentially through telomerase (h TERT) activation. Transcriptional …
telomere maintenance, essentially through telomerase (h TERT) activation. Transcriptional …
[HTML][HTML] Papillary thyroid cancer prognosis: An evolving field
S Ulisse, E Baldini, A Lauro, D Pironi, D Tripodi, E Lori… - Cancers, 2021 - mdpi.com
Simple Summary Over the last couple of decades, the prognostic stratification systems of
differentiated thyroid cancer (DTC) patients have been revised several times in an attempt to …
differentiated thyroid cancer (DTC) patients have been revised several times in an attempt to …
Performance of a multigene genomic classifier in thyroid nodules with indeterminate cytology: a prospective blinded multicenter study
DL Steward, SE Carty, RS Sippel, SP Yang… - JAMA …, 2019 - jamanetwork.com
Importance Approximately 20% of fine-needle aspirations (FNA) of thyroid nodules have
indeterminate cytology, most frequently Bethesda category III or IV. Diagnostic surgeries can …
indeterminate cytology, most frequently Bethesda category III or IV. Diagnostic surgeries can …
[HTML][HTML] Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to …
JM Oh, BC Ahn - Theranostics, 2021 - ncbi.nlm.nih.gov
The advanced, metastatic differentiated thyroid cancers (DTCs) have a poor prognosis
mainly owing to radioactive iodine (RAI) refractoriness caused by decreased expression of …
mainly owing to radioactive iodine (RAI) refractoriness caused by decreased expression of …
[HTML][HTML] Integrative analysis of genomic and transcriptomic characteristics associated with progression of aggressive thyroid cancer
Anaplastic thyroid cancer (ATC) and advanced differentiated thyroid cancers (DTCs) show
fatal outcomes, unlike DTCs. Here, we demonstrate mutational landscape of 27 ATCs and …
fatal outcomes, unlike DTCs. Here, we demonstrate mutational landscape of 27 ATCs and …
[HTML][HTML] Novel targeted therapies and immunotherapy for advanced thyroid cancers
Thyroid cancer is a frequently encountered endocrine malignancy. Despite the favorable
prognosis of this disease, 15–20% of differentiated thyroid cancer (DTC) cases and most …
prognosis of this disease, 15–20% of differentiated thyroid cancer (DTC) cases and most …
Molecular targets of tyrosine kinase inhibitors in thyroid cancer
P Fallahi, SM Ferrari, MR Galdiero, G Varricchi… - Seminars in Cancer …, 2022 - Elsevier
Thyroid cancer (TC) is the eighth most frequently diagnosed cancer worldwide with a rising
incidence in the past 20 years. Surgery is the primary strategy of therapy for patients with …
incidence in the past 20 years. Surgery is the primary strategy of therapy for patients with …
Mortality risk stratification by combining BRAF V600E and TERT promoter mutations in papillary thyroid cancer: genetic duet of BRAF and TERT promoter mutations in …
Importance BRAF V600E andTERTpromoter mutations can coexist in papillary thyroid
cancer (PTC). This genetic duet was indicated to be involved in the aggressiveness of PTC …
cancer (PTC). This genetic duet was indicated to be involved in the aggressiveness of PTC …
[HTML][HTML] Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer
The unique oncogene duet of coexisting BRAF V600E and TERT promoter mutations are
widely found to be a robust genetic background promoting human cancer aggressiveness …
widely found to be a robust genetic background promoting human cancer aggressiveness …
Multiplatform molecular test performance in indeterminate thyroid nodules
MA Lupo, AE Walts, JW Sistrunk… - Diagnostic …, 2020 - Wiley Online Library
Background Approximately 25% of thyroid nodule fine‐needle aspirates (FNAs) have
cytology that is indeterminate for malignant disease. Accurate risk stratification of these …
cytology that is indeterminate for malignant disease. Accurate risk stratification of these …