Mutation profiles of follicular thyroid tumors by targeted sequencing

H Duan, X Liu, X Ren, H Zhang, H Wu, Z Liang - Diagnostic Pathology, 2019 - Springer
Background One of the major challenges remaining in the classification of thyroid tumor is
the determination of whether a nodule is benign or malignant. We aimed to characterize the …

TERT promoter mutations in thyroid cancer

M Matsuse, N Mitsutake - Endocrine journal, 2023 - jstage.jst.go.jp
TERT promoter mutations (TERT-p mutations) have been found in many types of cancer and
have emerged to play critical roles in tumor progression. The mutations upregulate TERT …

The predictive value of coexisting BRAFV600E and TERT promoter mutations on poor outcomes and high tumour aggressiveness in papillary thyroid carcinoma: A …

B Chen, Y Shi, Y Xu, J Zhang - Clinical endocrinology, 2021 - Wiley Online Library
BRAFV600E mutation is highly prevalent in patients with papillary thyroid carcinoma (PTC),
and TERT promoter (TERTp) mutation is strongly associated with cancer‐related mortality …

A six-genotype genetic prognostic model for papillary thyroid cancer

X Shen, R Liu, M Xing - Endocrine-related cancer, 2017 - erc.bioscientifica.com
A unique prognostic role of the genetic duet of BRAF V600E and TERT promoter mutations
in papillary thyroid cancer (PTC) has been recently established, but the role of RAS mutation …

Whole-genome Sequencing of Follicular Thyroid Carcinomas Reveal Recurrent Mutations in MicroRNA Processing Subunit DGCR8

JO Paulsson, N Rafati, S DiLorenzo… - The Journal of …, 2021 - academic.oup.com
Background The genomic and transcriptomic landscape of widely invasive follicular thyroid
carcinomas (wiFTCs) and Hürthle cell carcinoma (HCC) are poorly characterized, and …

Intratumor heterogeneity in hepatocellular carcinoma: challenges and opportunities

SM Kalasekar, CH VanSant-Webb, KJ Evason - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is a deadly form of liver cancer that has
poor patient outcomes and survival. Unlike many other cancers, HCC has not seen the …

Thyroid cancers of follicular origin in a genomic light: in-depth overview of common and unique molecular marker candidates

N Pstrąg, K Ziemnicka, H Bluyssen, J Wesoły - Molecular cancer, 2018 - Springer
In recent years, thyroid malignances have become more prevalent, especially among
women. The most common sporadic types of thyroid tumors of follicular origin include …

Immune gene signature delineates a subclass of papillary thyroid cancer with unfavorable clinical outcomes

K Kim, S Jeon, TM Kim, CK Jung - Cancers, 2018 - mdpi.com
Papillary thyroid carcinoma (PTC) represents a heterogeneous disease with diverse clinical
outcomes highlighting a need to identify robust biomarkers with clinical relevance. We …

PD-L1 and IDO1 are expressed in poorly differentiated thyroid carcinoma

MW Rosenbaum, BJ Gigliotti, SI Pai, S Parangi… - Endocrine …, 2018 - Springer
Poorly differentiated thyroid carcinoma (PDTC) is an aggressive form of thyroid cancer that
currently has limited effective treatment options. Immune checkpoint inhibitors (ICIs) have …

DIAGNOSIS OF ENDOCRINE DISEASE: Usefulness of genetic testing of fine-needle aspirations for diagnosis of thyroid cancer

P Stewardson, M Eszlinger… - European Journal of …, 2022 - academic.oup.com
Objective Genetic testing is increasingly used to diagnose or rule out thyroid cancer in
indeterminate fine-needle aspirations. This review evaluates the usefulness of these …