[HTML][HTML] Regulation of immune responses by the airway epithelial cell landscape

RJ Hewitt, CM Lloyd - Nature Reviews Immunology, 2021 - nature.com
The community of cells lining our airways plays a collaborative role in the preservation of
immune homeostasis in the lung and provides protection from the pathogens and pollutants …

[HTML][HTML] Mucosal immune responses to infection and vaccination in the respiratory tract

RC Mettelman, EK Allen, PG Thomas - Immunity, 2022 - cell.com
The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …

Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality

C Zhang, Z Wu, JW Li, H Zhao, GQ Wang - International journal of …, 2020 - Elsevier
Since December 2019, a viral pneumonia, named coronavirus disease 2019 (COVID-19),
from Wuhan, China, has swept the world. Although the case fatality rate is not high, the …

The looming storm: blood and cytokines in COVID-19

S Kaur, R Bansal, S Kollimuttathuillam, AM Gowda… - Blood reviews, 2021 - Elsevier
A novel coronavirus termed as COVID-19 by WHO has been the causative agent of an
unprecedented pandemic in the history of humanity. The global burden of mortality and …

Role of airway epithelial barrier dysfunction in pathogenesis of asthma

Y Gon, S Hashimoto - Allergology International, 2018 - jstage.jst.go.jp
abstract Bronchial asthma is characterized by persistent cough, increased sputum, and
repeated wheezing. The pathophysiology underlying these symptoms is the hyper …

[HTML][HTML] Neuromechanisms of SARS-CoV-2: a review

MF DosSantos, S Devalle, V Aran, D Capra… - Frontiers in …, 2020 - frontiersin.org
Recent studies have suggested the neuroinvasive potential of severe acute respiratory
coronavirus 2 (SARS-CoV-2). Notably, neuroinvasiveness might be involved in the …

[HTML][HTML] Immunopathology of SARS-CoV-2 infection: immune cells and mediators, prognostic factors, and immune-therapeutic implications

A Allegra, M Di Gioacchino, A Tonacci… - International journal of …, 2020 - mdpi.com
The present is a comprehensive review of the immunopathology of Covid-19. The immune
reaction to SARS-CoV-2 infection is characterized by differentiation and proliferation of a …

[HTML][HTML] Lung epithelial cells: therapeutically inducible effectors of antimicrobial defense

MM Leiva-Juárez, JK Kolls, SE Evans - Mucosal immunology, 2018 - Elsevier
Lung epithelial cells are increasingly recognized to be active effectors of microbial defense,
contributing to both innate and adaptive immune function in the lower respiratory tract. As …

Combating COVID-19 and building immune resilience: a potential role for magnesium nutrition?

TC Wallace - Journal of the American College of Nutrition, 2020 - Taylor & Francis
Abstract Background: In December 2019, the viral pandemic of respiratory illness caused by
COVID-19 began sweeping its way across the globe. Several aspects of this infectious …

3D lung-on-chip model based on biomimetically microcurved culture membranes

D Baptista, L Moreira Teixeira, D Barata… - ACS biomaterials …, 2022 - ACS Publications
A comparatively straightforward approach to accomplish more physiological realism in
organ-on-a-chip (OoC) models is through substrate geometry. There is increasing evidence …