Outsmarting Pathogens with Antibody Engineering

AN Qerqez, RP Silva, JA Maynard - Annual Review of Chemical …, 2023 - annualreviews.org
There is growing interest in identifying antibodies that protect against infectious diseases,
especially for high-risk individuals and pathogens for which no vaccine is yet available …

The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase LasB

V Camberlein, G Jézéquel, J Haupenthal, AKH Hirsch - Antibiotics, 2022 - mdpi.com
Elastase B (LasB) is a zinc metalloprotease and a crucial virulence factor of Pseudomonas
aeruginosa. As the need for new strategies to fight antimicrobial resistance (AMR) constantly …

The involvement of the T6SS vgrG gene in the pathogenicity of Pseudomonas plecoglossicida

D Yang, L Zhao, Q Li, L Huang, Y Qin… - Journal of Fish …, 2023 - Wiley Online Library
Pseudomonas plecoglossicida, the causative agent of white spot disease of large yellow
croaker, has caused serious economic losses to the aquaculture industry. The type VI …

Catalytic antibodies: Design, expression, and their applications in medicine

D Zhao, J Chen, X Hu, S Zhang - Applied Biochemistry and Biotechnology, 2023 - Springer
Catalytic antibodies made it feasible to develop new catalysts, which had previously been
the subject of research. Scientists have discovered natural antibodies that can hydrolyze …

Computational discovery of binding mode of anti-TRBC1 antibody and predicted key amino acids of TRBC1

J Saetang, S Sangkhathat, N Jangphattananont… - Scientific Reports, 2022 - nature.com
Peripheral T-cell lymphoma (PTCL) is a type of non-Hodgkin lymphoma that progresses
aggressively with poor survival rate. CAR T cell targeting T-cell receptor β-chain constant …

Quercetin: a promising virulence inhibitor of Pseudomonas aeruginosa LasB in vitro

Y Ren, R Zhu, X You, D Li, M Guo, B Fei, Y Liu… - Applied Microbiology …, 2024 - Springer
With the inappropriate use of antibiotics, antibiotic resistance has emerged as a major
dilemma for patients infected with Pseudomonas aeruginosa. Elastase B (LasB), a crucial …

Novel Antimicrobials, Drug Delivery Systems and Antivirulence Targets in the Pipeline—From Bench to Bedside

O Săndulescu, I Viziteu, A Streinu-Cercel, VD Miron… - Applied Sciences, 2022 - mdpi.com
In a fast-paced medical reality, biosciences and bioengineering have become essential
components in medical research and development. The aim of this paper is to characterize …

Detection via in vitro amplification of lasR gene associated with virulent attribute of Pseudomonas aeruginosa from acute pulmonary infections

NM Ali, U Hanif, S Taj, S Bahadur, M Shuaib - Gene Reports, 2022 - Elsevier
Pseudomonas aeruginosa is the most ubiquitous pulmonary pathogen of human which
causes successfully unscrupulous infections in patients with the suppressed immune system …

[PDF][PDF] Bacterial biofilm interactions with human immune cells

K Lee - 2022 - core.ac.uk
Innate immune cells recognise pathogens via specific receptors able to distinguish
structures unique to microorganisms, deemed pathogen associated molecular patterns …

Contributions of antibodies binding defined epitopes to protection against B. pertussis and SARS-CoV-2

RP Silva - 2022 - repositories.lib.utexas.edu
While antibodies have the potential to reduce the severity of many infections and prevent
transmission of pathogens, microbes have a corresponding capacity to undermine these …