[HTML][HTML] Genetic predispositions of Parkinson's disease revealed in patient-derived brain cells
J Tran, H Anastacio, C Bardy - NPJ Parkinson's disease, 2020 - nature.com
Parkinson's disease (PD) is the second most prevalent neurological disorder and has been
the focus of intense investigations to understand its etiology and progression, but it still lacks …
the focus of intense investigations to understand its etiology and progression, but it still lacks …
[HTML][HTML] Stem and progenitor cell-based therapy of the central nervous system: hopes, hype, and wishful thinking
SA Goldman - Cell stem cell, 2016 - cell.com
A variety of neurological disorders are attractive targets for stem and progenitor cell-based
therapy. Yet many conditions are not, whether by virtue of an inhospitable disease …
therapy. Yet many conditions are not, whether by virtue of an inhospitable disease …
[HTML][HTML] ApoE-isoform-dependent SARS-CoV-2 neurotropism and cellular response
ApoE4, a strong genetic risk factor for Alzheimer disease, has been associated with
increased risk for severe COVID-19. However, it is unclear whether ApoE4 alters COVID-19 …
increased risk for severe COVID-19. However, it is unclear whether ApoE4 alters COVID-19 …
[HTML][HTML] Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects
Aging is a major risk factor for many human diseases, and in vitro generation of human
neurons is an attractive approach for modeling aging-related brain disorders. However …
neurons is an attractive approach for modeling aging-related brain disorders. However …
Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro
C Bardy, M Van Den Hurk, T Eames… - Proceedings of the …, 2015 - National Acad Sciences
Human cell reprogramming technologies offer access to live human neurons from patients
and provide a new alternative for modeling neurological disorders in vitro. Neural electrical …
and provide a new alternative for modeling neurological disorders in vitro. Neural electrical …
Advances in microfluidic in vitro systems for neurological disease modeling
PM Holloway, S Willaime‐Morawek… - Journal of …, 2021 - Wiley Online Library
Neurological disorders are the leading cause of disability and the second largest cause of
death worldwide. Despite significant research efforts, neurology remains one of the most …
death worldwide. Despite significant research efforts, neurology remains one of the most …
[HTML][HTML] Stem cell transplantation therapy and neurological disorders: current status and future perspectives
Simple Summary This review highlights the scope of available treatment options for
neurological diseases, especially stem cell transplantation therapy, which provides new …
neurological diseases, especially stem cell transplantation therapy, which provides new …
Joubert syndrome: congenital cerebellar ataxia with the molar tooth
M Romani, A Micalizzi, EM Valente - The Lancet Neurology, 2013 - thelancet.com
Joubert syndrome is a congenital cerebellar ataxia with autosomal recessive or X-linked
inheritance, the diagnostic hallmark of which is a unique cerebellar and brainstem …
inheritance, the diagnostic hallmark of which is a unique cerebellar and brainstem …
Mitochondrial dysfunction: a potential therapeutic target to treat Alzheimer's disease
Mitochondrial dysfunction plays a very vital role in the pathogenesis of Alzheimer's disease
(AD). Several shreds of evidence have indicated that the mitochondrial function is severely …
(AD). Several shreds of evidence have indicated that the mitochondrial function is severely …
Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons
K Griesi-Oliveira, A Acab, AR Gupta, DY Sunaga… - Molecular …, 2015 - nature.com
An increasing number of genetic variants have been implicated in autism spectrum
disorders (ASDs), and the functional study of such variants will be critical for the elucidation …
disorders (ASDs), and the functional study of such variants will be critical for the elucidation …