[HTML][HTML] Genetic predispositions of Parkinson's disease revealed in patient-derived brain cells

J Tran, H Anastacio, C Bardy - NPJ Parkinson's disease, 2020 - nature.com
Parkinson's disease (PD) is the second most prevalent neurological disorder and has been
the focus of intense investigations to understand its etiology and progression, but it still lacks …

[HTML][HTML] Stem and progenitor cell-based therapy of the central nervous system: hopes, hype, and wishful thinking

SA Goldman - Cell stem cell, 2016 - cell.com
A variety of neurological disorders are attractive targets for stem and progenitor cell-based
therapy. Yet many conditions are not, whether by virtue of an inhospitable disease …

[HTML][HTML] ApoE-isoform-dependent SARS-CoV-2 neurotropism and cellular response

C Wang, M Zhang, G Garcia, E Tian, Q Cui, X Chen… - Cell stem cell, 2021 - cell.com
ApoE4, a strong genetic risk factor for Alzheimer disease, has been associated with
increased risk for severe COVID-19. However, it is unclear whether ApoE4 alters COVID-19 …

[HTML][HTML] Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects

J Mertens, ACM Paquola, M Ku, E Hatch, L Böhnke… - Cell stem cell, 2015 - cell.com
Aging is a major risk factor for many human diseases, and in vitro generation of human
neurons is an attractive approach for modeling aging-related brain disorders. However …

Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro

C Bardy, M Van Den Hurk, T Eames… - Proceedings of the …, 2015 - National Acad Sciences
Human cell reprogramming technologies offer access to live human neurons from patients
and provide a new alternative for modeling neurological disorders in vitro. Neural electrical …

Advances in microfluidic in vitro systems for neurological disease modeling

PM Holloway, S Willaime‐Morawek… - Journal of …, 2021 - Wiley Online Library
Neurological disorders are the leading cause of disability and the second largest cause of
death worldwide. Despite significant research efforts, neurology remains one of the most …

[HTML][HTML] Stem cell transplantation therapy and neurological disorders: current status and future perspectives

MM Rahman, MR Islam, MT Islam, M Harun-Or-Rashid… - Biology, 2022 - mdpi.com
Simple Summary This review highlights the scope of available treatment options for
neurological diseases, especially stem cell transplantation therapy, which provides new …

Joubert syndrome: congenital cerebellar ataxia with the molar tooth

M Romani, A Micalizzi, EM Valente - The Lancet Neurology, 2013 - thelancet.com
Joubert syndrome is a congenital cerebellar ataxia with autosomal recessive or X-linked
inheritance, the diagnostic hallmark of which is a unique cerebellar and brainstem …

Mitochondrial dysfunction: a potential therapeutic target to treat Alzheimer's disease

SN Rai, C Singh, A Singh, MP Singh, BK Singh - Molecular Neurobiology, 2020 - Springer
Mitochondrial dysfunction plays a very vital role in the pathogenesis of Alzheimer's disease
(AD). Several shreds of evidence have indicated that the mitochondrial function is severely …

Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons

K Griesi-Oliveira, A Acab, AR Gupta, DY Sunaga… - Molecular …, 2015 - nature.com
An increasing number of genetic variants have been implicated in autism spectrum
disorders (ASDs), and the functional study of such variants will be critical for the elucidation …