The nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of redox balance
and it responds to various cell stresses that oxidative stress is the most well-known one. The …

Chronic heart failure (CHF) is a severe public health problem with increasing morbidity and
mortality, any treatment targeting a single session is insufficient to tackle this. CHF is …

Network pharmacology for systematic understanding of Schisandrin B reduces the epithelial
cells injury of colitis through regulating pyroptosis by AMPK/Nrf2/NLRP3 inflammasome - PMC …

Plant lignans exhibit a wide range of biological activities, which makes them the research
objects of potential use as therapeutic agents. They provide diverse naturally-occurring …

Background Acute lung injury (ALI) is a challenging clinical syndrome that manifests as an
acute inflammatory response. Schisandrin B (Sch B), a bioactive lignan from Schisandra …

Oxidative stress following liver ischemia/reperfusion (I/R) is an important pathological
mechanism responsible for liver injury. Veratric acid (VA) is a phenolic benzoic acid that has …

Objective Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) can regulate
numerous biological processes and is implicated in diverse pathological processes. Yet its …

Objective To investigate the effects of phillyrin on D-galactose (D-gal)-induced aging in the
brain of mice and mechanism. Methods Institute of Cancer Research mice were …

Heart Failure (HF) epitomizes a formidable global health quandary characterized by marked
morbidity and mortality. It has been established that severe derangements in energy …

Osteosarcoma is the most common primary malignant bone tumor; the main treatment
method is surgery and adjuvant chemotherapy, with a 5-year survival rate of less than 20 …