Human T cell leukemia virus type 1: persistence and pathogenesis

CRM Bangham - Annual review of immunology, 2018 - annualreviews.org
Human T cell leukemia virus type 1 (HTLV-1), also known as human T lymphotropic virus
type 1, was the first exogenous human retrovirus discovered. Unlike the distantly related …

HTLV-1 bZIP factor: the key viral gene for pathogenesis

M Matsuoka, JM Mesnard - Retrovirology, 2020 - Springer
Human T cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia-lymphoma (ATL)
and inflammatory diseases. The HTLV-1 bZIP factor (HBZ) gene is constantly expressed in …

Revised adult T-cell leukemia-lymphoma international consensus meeting report

LB Cook, S Fuji, O Hermine, A Bazarbachi… - Journal of Clinical …, 2019 - ascopubs.org
Purpose Adult T-cell leukemia-lymphoma (ATL) is a distinct mature T-cell malignancy
caused by chronic infection with human T-lymphotropic virus type 1 with diverse clinical …

HTLV-1 infection promotes excessive T cell activation and transformation into adult T cell leukemia/lymphoma

BJY Tan, K Sugata, O Reda, M Matsuo… - The Journal of …, 2021 - Am Soc Clin Investig
Human T cell leukemia virus type 1 (HTLV-1) mainly infects CD4+ T cells and induces
chronic, persistent infection in infected individuals, with some developing adult T cell …

Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells

M Mahgoub, J Yasunaga, S Iwami… - Proceedings of the …, 2018 - National Acad Sciences
Viruses causing chronic infection artfully manipulate infected cells to enable viral
persistence in vivo under the pressure of immunity. Human T-cell leukemia virus type 1 …

Size-dependent increase in RNA polymerase II initiation rates mediates gene expression scaling with cell size

XM Sun, A Bowman, M Priestman, F Bertaux… - Current Biology, 2020 - cell.com
Cell size varies during the cell cycle and in response to external stimuli. This requires the
tight coordination, or" scaling," of mRNA and protein quantities with the cell volume in order …

[HTML][HTML] 40 years of the human T-cell leukemia virus: past, present, and future

Y Tagaya, M Matsuoka, R Gallo - F1000Research, 2019 - ncbi.nlm.nih.gov
It has been nearly 40 years since human T-cell leukemia virus-1 (HTLV-1), the first
oncogenic retrovirus in humans and the first demonstrable cause of cancer by an infectious …

Identification and characterization of a novel enhancer in the HTLV-1 proviral genome

M Matsuo, T Ueno, K Monde, K Sugata… - Nature …, 2022 - nature.com
Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic virus with constantly active
antisense transcription from the proviral genome. Here, Matsuo et al. perform proviral DNA …

HTLV-1 extracellular vesicles promote cell-to-cell contact

DO Pinto, C DeMarino, ML Pleet, M Cowen… - Frontiers in …, 2019 - frontiersin.org
Human T-cell leukemia virus-1 (HTLV-1) is a neglected and incurable retrovirus estimated to
infect 5 to 10 million worldwide. Specific indigenous Australian populations report infection …

NF螃B signaling mechanisms in HTLV1induced adult Tcell leukemia/lymphoma

EW Harhaj, CZ Giam - The FEBS journal, 2018 - Wiley Online Library
The human Tcell leukemia virus type 1 (HTLV1) is a complex deltaretrovirus linked to
adult Tcell leukemia/lymphoma (ATLL), a fatal CD 4+ malignancy in 3–5% of infected …