An innovative phase 2 proof‐of‐concept trial design to evaluate SAR445088, a monoclonal antibody targeting complement C1s in chronic inflammatory demyelinating …

L Querol, RA Lewis, HP Hartung… - Journal of the …, 2023 - Wiley Online Library
Abstract Background and Aims Chronic inflammatory demyelinating polyneuropathy (CIDP)
is a rare immune‐mediated disease of the peripheral nerves, with significant unmet …

Machine learning vs. survival analysis models: a study on right censored heart failure data

B Srujana, D Verma, S Naqvi - Communications in Statistics …, 2024 - Taylor & Francis
Abstract Machine Learning Models are known to understand the intricacies of the data well,
but native ML models cannot be used in time-to-event analysis due to censoring. In this …

Minimally invasive surgery with thrombolysis for intracerebral hemorrhage evacuation: Bayesian reanalysis of a randomized controlled trial

AT Bako, T Potter, AP Pan, J Tannous, G Britz, WC Ziai… - Neurology, 2023 - AAN Enterprises
Background and Objectives Bayesian analysis of randomized controlled trials (RCTs) can
extend the value of trial data beyond interpretations based on conventional p value–based …

Multitask-Guided Self-Supervised Tabular Learning for Patient-Specific Survival Prediction

Y Wu, O Bazgir, Y Lee, T Biancalani… - Machine Learning …, 2024 - proceedings.mlr.press
Survival prediction, central to the analysis of clinical trials, has the potential to be
transformed by the availability of RNA-seq data as it reveals the underlying molecular and …

Clinical trial considerations for pediatric cancer drug development

F Cooner, J Ye, G Reaman - Journal of Biopharmaceutical Statistics, 2023 - Taylor & Francis
Oncology has been one of the most active therapeutic areas in medicinal products
development. Despite this fact, few drugs have been approved for use in pediatric cancer …

Bayesian Survival Dagum 3 Parameter Link Function Models in the Suppression of Dengue Fever in Bojonegoro

N Mahmudah, F Anggraini - Bayesian Survival Dagum 3 …, 2021 - repository.unugiri.ac.id
Dengue Hemorrhagic Fever (DHF) is currently attacking residential areas unprepared to
prevent the spread of the Aedes Aegypti mosquito. This has resulted in many residents …

Mathematical Oncology to Integrate Multimodal Clinical and Liquid Biopsy Data for the Prediction of Survival

LJ Ndacayisaba, J Mason, P Kuhn - Circulating Tumor Cells: Advances in …, 2023 - Springer
The complex multimodality in clinical and liquid biopsy data generated by multiparametric
diagnostic and tumor profiling technologies presents an exciting opportunity for developing …

Bayesian generalized method of moments applied to pseudo-observations in survival analysis

L Orsini, C Brard, E Lesaffre, G Yin, D Dejardin… - 2024 - hal.science
Bayesian inference for survival regression modeling offers numerous advantages,
especially for decision-making and external data borrowing, but demands the specification …

PARAMETRIC MODELLING USING BAYESIAN APPROACH

J Consul, E Osaisai, J Bunakiye… - Unilag Journal of …, 2022 - lagjma.unilag.edu.ng
PARAMETRIC MODELLING USING BAYESIAN APPROACH 1. Introduction Survival
analysis is one of the most important fields of Statistics Page 1 Unilag Journal of …

[PDF][PDF] Extending Bayesian evidence synthesis to include historical trial data for improved survival extrapolations from early data cuts in metastatic non-small cell lung …

DJ Sharpe, G Yates, L García-Fernández, Y Yuan… - ispor.org
Conclusions• When relevant historical trial data are integrated into a survival model
appropriately, this information can improve the reliability of short-and long-term …