The N-methyl-d-aspartate receptor (NMDAR) antagonist (R, S)-ketamine causes rapid onset
and sustained antidepressant actions in treatment-resistant patients with major depressive …

Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

Neuropsychiatric disorders, which are associated with stress hormone dysregulation, occur
at different rates in men and women. Moreover, nowadays, preclinical and clinical evidence …

Stress is a major risk factor for psychiatric disorders. During and after exposure to stressors,
the stress response may have pro-or maladaptive consequences, depending on several …

Post-traumatic stress disorder (PTSD) is usually considered a psychiatric disorder upon
emotional trauma. However, with the rising number of conflicts and traffic accidents around …

Mood disorders are the most prevalent psychiatric disorders associated with significant
disability, morbidity, and mortality. The risk of suicide is associated with severe or mixed …

Women suffer from depression at twice the rate of men, but the underlying molecular
mechanisms are poorly understood. Here, we identify marked baseline sex differences in …

Abstract (R, S)-ketamine is known to elicit persistent prophylactic effects in rodent models of
depression. However, the precise molecular mechanisms underlying its action remain …

The eight biological hallmarks of health that we initially postulated (Cell. 2021 Jan 7; 184 (1):
33-63) include features of spatial compartmentalization (integrity of barriers, containment of …

Emerging evidence suggests that brain derived extracellular vesicles (EVs) and particles
(EPs) can cross blood-brain barrier and mediate communication among neurons, astrocytes …