Pineapple has been used as part of traditional folk medicine since ancient times and it
continues to be present in various herbal preparations. Bromelain is a complex mixture of …

Bromelain belongs to a group of protein digesting enzymes obtained commercially from the
fruit or stem of pineapple. Fruit bromelain and stem bromelainare prepared differently and …

Bromelain is a complex combination of multiple endopeptidases of thiol and other
compounds derived from the pineapple fruit, stem and/or root. Fruit bromelain and stem …

Cancer is one of the main causes of death globally and considered as a major challenge for
the public health system. The high toxicity and the lack of selectivity of conventional …

The medicinal qualities of pineapple are recognized in many traditions in South America,
China and Southeast Asia. These qualities are attributed to bromelain, a 95%-mixture of …

Natural products with immunomodulatory activity are widely used in treatment of many
diseases including autoimmune diseases, inflammatory disorders in addition to cancer …

Advanced colorectal cancer (CRC) survival rates are still low despite advances in cytotoxic
and targeted therapies. The development of new effective or alternative therapies is …

Abstract Stem bromelain (EC 3.4. 22.32) is a major cysteine proteinase, isolated from
pineapple (Ananas comosus) stem. Its main medicinal use is recognized as digestive, in …

OBJECTIVE: Bromelain, a clinically used pineapple extract and natural product, has
reported anti-inflammatory and immunomodulatory activities. The purpose of this study was …

Cysteine proteinases are involved in virtually every aspect of plant physiology and
development. They play a role in development, senescence, programmed cell death …