Spinal cord injury can lead to severe motor, sensory and autonomic dysfunction. Currently,
there is no effective treatment for the injured spinal cord. The transplantation of Schwann …

Spinal cord injury (SCI) often leads to the loss of motor and sensory functions and is a major
challenge in neurological clinical practice. Understanding the pathophysiological changes …

Adult neurogenesis plays critical roles in maintaining brain homeostasis and responding to
neurogenic insults. However, the adult mammalian spinal cord lacks an intrinsic capacity for …

Mature oligodendrocytes (MOLs) show transcriptional heterogeneity, the functional
consequences of which are unclear. MOL heterogeneity might correlate with the local …

Our previous studies showed that ferroptosis plays an important role in the acute and
subacute stages of spinal cord injury. High intracellular iron levels and low glutathione …

Fighting pathogens and maintaining tissue homeostasis are prerequisites for survival. Both
of these functions are upheld by the immune system, though the latter is often overlooked in …

Inflammation is a prominent feature of CNS injury that heavily influences neuronal survival,
yet the signals that initiate and control it remain poorly understood. Here we identify the …

Several distinct cell types in the adult central nervous system have been suggested to act as
stem or progenitor cells generating new cells under physiological or pathological conditions …

Spinal cord injury (SCI) is a neurological disorder associated with the loss of sensory and
motor function. Understanding the precise dysregulated signaling pathways, especially …

Spinal cord injury often results in permanent functional impairment. Neural stem cells
present in the adult spinal cord can be expanded in vitro and improve recovery when …