Cathepsin D as a promising target for the discovery of novel anticancer agents

V Dubey, S Luqman - Current cancer drug targets, 2017 - ingentaconnect.com
Background: Cathepsin D (CATD), one of the aspartyl endoproteinase involved in different
physiological processes and signaling pathways, is accountable for metabolic breakdown of …

Ellagic acid modulates the expression of oral innate immune mediators: Potential role in mucosal protection

A Promsong, WO Chung, S Satthakarn… - Journal of Oral …, 2015 - Wiley Online Library
Background Ellagic acid (EA) found in various fruits such as pomegranates, blackberries,
raspberries, strawberries, and walnuts has different pharmacological functions including …

Ellagic acid inhibits the formation of hypertrophic scars by suppressing TGF‐β/Smad signaling pathway activity

Z Zhao, D Wu, D Lv, B Zhang, L Chen… - Chemical Biology & …, 2023 - Wiley Online Library
Hypertrophic scar (HS) is a benign fibroproliferative skin disease, which lacks the ideal
treatment and drugs. Ellagic acid (EA) is a natural polyphenol that prevents fibroblasts from …

Orientin, a C-glycosyl dietary flavone, suppresses colonic cell proliferation and mitigates NF-κB mediated inflammatory response in 1, 2-dimethylhydrazine induced …

K Thangaraj, M Vaiyapuri - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Orientin, a C-glycosyl dietary flavone profusely found in rooibos tea and passion fruit have
gained much attention owing to their multiple pharmacological potentials. The present study …

Jelly Fig (Ficus awkeotsang Makino) Exhibits Antioxidative and Anti-Inflammatory Activities by Regulating Reactive Oxygen Species Production via NFκB Signaling …

MJ Lin, P Lin, KC Wen, HM Chiang, MC Lu - Antioxidants, 2022 - mdpi.com
Antioxidant and anti-inflammatory activities of Ficus awkeotsang Makino extract (FAE) on
Hs68 fibroblasts and BALB/c nude-mouse models are evaluated in this study. FAE was …

Molecular and biochemical evidence on the protective role of ellagic acid and silybin against oxidative stress-induced cellular aging

M Baeeri, S Mohammadi-Nejad, M Rahimifard… - Molecular and Cellular …, 2018 - Springer
Aging is a natural process in living organisms that is defined by some molecular and cellular
changes with time. Various causes such as mitochondrial DNA aberrations, aggregation of …

[HTML][HTML] Modulators affecting the immune dialogue between human immune and colon cancer cells

M Djaldetti, H Bessler - World journal of gastrointestinal oncology, 2014 - ncbi.nlm.nih.gov
The link between chronic inflammation and colorectal cancer has been well established.
The events proceeding along tumorigenesis are complicated and involve cells activated at …

[PDF][PDF] Neuroprotective effect of ellagic acid against chronically scopolamine induced Alzheimer's type memory and cognitive dysfunctions: Possible behavioural and …

R Kaur, S Parveen, S Mehan, D Khanna… - Int. J. Preven. Med …, 2015 - academia.edu
Adjudge the neuroprotective ability of Ellagic acid (EA) as a constructive herbal drug to
impede cholinergic dysfunctions and oxidative stress in Alzheimer's disease (AD) in …

Effect of Cichorium intybus L. on the expression of hepatic NF-κB and IKKβ and serum TNF-α in STZ− and STZ+ niacinamide-induced diabetes in rats

L Rezagholizadeh, Y Pourfarjam, A Nowrouzi… - Diabetology & Metabolic …, 2016 - Springer
Background Inflammation is an early event in the development of diabetes type 2 (T2D).
Cichorium intybus L.(chicory) possesses anti-inflammatory action. We compared the anti …

Multiple effects of ellagic acid on human colorectal carcinoma cells identified by gene expression profile analysis

J Zhao, G Li, W Bo, Y Zhou… - International …, 2017 - spandidos-publications.com
Colorectal carcinoma (CRC) is the third most commonly diagnosed cancer in the world.
Phytochemicals have become a research hotspot in recent years as cancer prevention and …