MicroRNAs (miRNAs) are a group of endogenous non-coding RNAs that regulate gene
expression. Alteration in miRNA expression results in changes in the profile of genes …

Oligonucleotides can be used to modulate gene expression via a range of processes
including RNAi, target degradation by RNase H-mediated cleavage, splicing modulation …

血管内皮细胞和内皮细胞释放的活性因子是调控血管舒张功能的重要因素. 糖尿病是慢性心血管
疾病的高危因素之一. 目前认为高糖和糖尿病引起的内皮细胞功能障碍是造成血管功能改变 …

Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of chronic liver
disease in the Western world, probably due to the growing prevalence of obesity, metabolic …

Obesity is a complex condition that is characterized by excessive fat accumulation, which
can lead to the development of metabolic disorders, such as type 2 diabetes mellitus …

MicroRNAs are small noncoding transcripts that posttranscriptionally regulate gene
expression via base-pairing complementarity. Their role in cancer can be related to tumor …

Metabolic disorders are characterized by the inability to properly use and/or store energy.
The burdens of metabolic disease, such as obesity or diabetes, are believed to arise through …

A main challenge in realizing the full potential of nucleic acid therapeutics is efficient
delivery of them into targeted tissues and cells. N-acetylgalactosamine (GalNAc) is a well …

The most frequent recurring mutations in neurofibromatosis type 1 (NF1) are large deletions
encompassing the NF1 gene and its flanking regions (NF1 microdeletions). The majority of …

Objective Exosomes from obese adipose contain dysregulated microRNAs linked to insulin
signaling, as compared with lean controls, providing a direct connection between adiposity …