The therapeutic potential of glucagon-like peptide-1 for persons with addictions based on findings from preclinical and clinical studies
E Jerlhag - Frontiers in Pharmacology, 2023 - frontiersin.org
Although the multifaceted mechanisms underlying alcohol use disorder (AUD) have been
partially defined, the neurobiological complexity of this disorder is yet to be unraveled. One …
partially defined, the neurobiological complexity of this disorder is yet to be unraveled. One …
Metabolic hormone action in the VTA: Reward-directed behavior and mechanistic insights
CE Geisler, MR Hayes - Physiology & behavior, 2023 - Elsevier
Dysfunctional signaling in midbrain reward circuits perpetuates diseases characterized by
compulsive overconsumption of rewarding substances such as substance abuse, binge …
compulsive overconsumption of rewarding substances such as substance abuse, binge …
Pharmacological GHSR (ghrelin receptor) blockade reduces alcohol binge-like drinking in male and female mice
RS Richardson, A Sulima, KC Rice, JA Kucharczk… - …, 2023 - Elsevier
Ghrelin is a peptide that is produced by endocrine cells that are primarily localized in the
stomach. Ghrelin receptors (GHSR) are expressed in the brain and periphery. Preclinical …
stomach. Ghrelin receptors (GHSR) are expressed in the brain and periphery. Preclinical …
Brain regulation of hunger and motivation: The case for integrating homeostatic and hedonic concepts and its implications for obesity and addiction
I Morales - Appetite, 2022 - Elsevier
Obesity and other eating disorders are marked by dysregulations to brain metabolic,
hedonic, motivational, and sensory systems that control food intake. Classic approaches in …
hedonic, motivational, and sensory systems that control food intake. Classic approaches in …
Role of the ghrelin system in alcohol use disorder and alcohol‐associated liver disease: A narrative review
KK Kharbanda, M Farokhnia… - Alcoholism: Clinical …, 2022 - Wiley Online Library
Unhealthy alcohol consumption is a global health problem. Adverse individual, public
health, and socioeconomic consequences are attributable to harmful alcohol use …
health, and socioeconomic consequences are attributable to harmful alcohol use …
An overview of appetite-regulatory peptides in addiction processes; from bench to bed side
OT Shevchouk, M Tufvesson-Alm… - Frontiers in Neuroscience, 2021 - frontiersin.org
There is a substantial need for new pharmacological treatments of addiction, and appetite-
regulatory peptides are implied as possible candidates. Appetite regulation is complex and …
regulatory peptides are implied as possible candidates. Appetite regulation is complex and …
Are signals regulating energy homeostasis related to neuropsychological and clinical features of gambling disorder? A case–control study
M Etxandi, I Baenas, B Mora-Maltas, R Granero… - Nutrients, 2022 - mdpi.com
Gambling disorder (GD) is a modestly prevalent and severe condition for which
neurobiology is not yet fully understood. Although alterations in signals involved in energy …
neurobiology is not yet fully understood. Although alterations in signals involved in energy …
[HTML][HTML] Complexes of ghrelin GHS-R1a, GHS-R1b, and dopamine D1 receptors localized in the ventral tegmental area as main mediators of the dopaminergic effects …
Ghrelin receptor, also known as growth hormone secretagogue receptor (GHS-R1a), is
coexpressed with its truncated isoform GHS-R1b, which does not bind ghrelin or signal, but …
coexpressed with its truncated isoform GHS-R1b, which does not bind ghrelin or signal, but …
Animal studies reveal that the ghrelin pathway regulates alcohol-mediated responses
E Jerlhag - Frontiers in Psychiatry, 2023 - frontiersin.org
Alcohol use disorder (AUD) is often described as repeated phases of binge drinking,
compulsive alcohol-taking, craving for alcohol during withdrawal, and drinking with an aim to …
compulsive alcohol-taking, craving for alcohol during withdrawal, and drinking with an aim to …
Advances in the development of nonpeptide small molecules targeting ghrelin receptor
G Giorgioni, F Del Bello, W Quaglia… - Journal of Medicinal …, 2022 - ACS Publications
Ghrelin is an octanoylated peptide acting by the activation of the growth hormone
secretagogue receptor, namely, GHS-R1a. The involvement of ghrelin in several …
secretagogue receptor, namely, GHS-R1a. The involvement of ghrelin in several …