Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs
RNA plays a central role in the expression of all genes. Because any sequence within RNA
can be recognized by complementary base pairing, synthetic oligonucleotides and …
can be recognized by complementary base pairing, synthetic oligonucleotides and …
Non-coding RNAs as drug targets
M Matsui, DR Corey - Nature reviews Drug discovery, 2017 - nature.com
Most of the human genome encodes RNAs that do not code for proteins. These non-coding
RNAs (ncRNAs) may affect normal gene expression and disease progression, making them …
RNAs (ncRNAs) may affect normal gene expression and disease progression, making them …
miR-15 and miR-16 induce apoptosis by targeting BCL2
Chronic lymphocytic leukemia (CLL) is the most common human leukemia and is
characterized by predominantly nondividing malignant B cells overexpressing the …
characterized by predominantly nondividing malignant B cells overexpressing the …
The Id-protein family in developmental and cancer-associated pathways
C Roschger, C Cabrele - Cell Communication and Signaling, 2017 - Springer
Inhibitors of DNA binding and cell differentiation (Id) proteins are members of the large
family of the helix-loop-helix (HLH) transcription factors, but they lack any DNA-binding motif …
family of the helix-loop-helix (HLH) transcription factors, but they lack any DNA-binding motif …
Mitochondria: The metabolic switch of cellular oncogenic transformation
Mitochondria, well recognized as the “powerhouse” of cells, are maternally inherited
organelles with bacterial ancestry that play essential roles in a myriad of cellular functions. It …
organelles with bacterial ancestry that play essential roles in a myriad of cellular functions. It …
HA14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells
J Skommer, D Wlodkowic, M Mättö, M Eray… - Leukemia research, 2006 - Elsevier
The BCL-2 overexpression is a hallmark of follicular lymphoma (FL). Since patients with FL
often suffer from resistant to chemotherapy refractory disease, the development of new …
often suffer from resistant to chemotherapy refractory disease, the development of new …
Death receptor signals to the mitochondria
R Khosravi-Far - Cancer biology & therapy, 2004 - Taylor & Francis
Apoptosis is the best-characterized form of programmed cell death (PCD) and is of
fundamental importance in tissue homeostasis. In mammalian systems, there are two major …
fundamental importance in tissue homeostasis. In mammalian systems, there are two major …
Targeting tumor microenvironment with PEG-based amphiphilic nanoparticles to overcome chemoresistance
Multidrug resistance is one of the biggest obstacles in the treatment of cancer. Recent
research studies highlight that tumor microenvironment plays a predominant role in tumor …
research studies highlight that tumor microenvironment plays a predominant role in tumor …
Emerging pathways in the development of chondrosarcoma of bone and implications for targeted treatment
JVMG Bovée, AM Cleton-Jansen… - The lancet …, 2005 - thelancet.com
Chondrosarcoma is a malignant cartilage-forming tumour of bone, of which distinct
clinicopathological subtypes are known. Conventional chondrosarcoma is notorious for its …
clinicopathological subtypes are known. Conventional chondrosarcoma is notorious for its …
METTL3‑mediated m6A modification of Bcl‑2 mRNA promotes non‑small cell lung cancer progression Corrigendum in/10.3892/or. 2023.8502
Y Zhang, S Liu, T Zhao, C Dang - Oncology Reports, 2021 - spandidos-publications.com
Abstract Methyltransferase‑like 3 (METTL3) is an RNA methyltransferase that mediates
modification of N6‑methyladenosine (m6A), which serves as an oncogene in various types …
modification of N6‑methyladenosine (m6A), which serves as an oncogene in various types …