Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene
ZH Chen, YP Yu, ZH Zuo, JB Nelson… - Nature …, 2017 - nature.com
Specifically targeting genomic rearrangements and mutations in tumor cells remains an
elusive goal in cancer therapy. Here, we used Cas9-based genome editing to introduce the …
elusive goal in cancer therapy. Here, we used Cas9-based genome editing to introduce the …
Reducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array
Abstract Background The Illumina HumanMethylation450 BeadChip (HM450K) measures
the DNA methylation of 485,512 CpGs in the human genome. The technology relies on …
the DNA methylation of 485,512 CpGs in the human genome. The technology relies on …
Identification of recurrent fusion genes across multiple cancer types
YP Yu, P Liu, J Nelson, RL Hamilton, R Bhargava… - Scientific reports, 2019 - nature.com
Chromosome changes are one of the hallmarks of human malignancies. Chromosomal
rearrangement is frequent in human cancers. One of the consequences of chromosomal …
rearrangement is frequent in human cancers. One of the consequences of chromosomal …
DNA methylation landscapes of prostate cancer brain metastasis are shaped by early driver genetic alterations
Metastases from primary prostate cancers to rare locations, such as the brain, are becoming
more common due to longer life expectancy resulting from improved treatments. Epigenetic …
more common due to longer life expectancy resulting from improved treatments. Epigenetic …
[HTML][HTML] Novel fusion transcripts associate with progressive prostate cancer
The mechanisms underlying the potential for aggressive behavior of prostate cancer (PCa)
remain elusive. In this study, whole genome and/or transcriptome sequencing was …
remain elusive. In this study, whole genome and/or transcriptome sequencing was …
Man2a1–fer fusion gene is expressed by human liver and other tumor types and has oncogenic activity in mice
Background & Aims Human tumors and liver cancer cell lines express the product of a fusion
between the first 13 exons in the mannosidase α class 2A member 1 gene (MAN2A1) and …
between the first 13 exons in the mannosidase α class 2A member 1 gene (MAN2A1) and …
Methylome-wide sequencing detects DNA hypermethylation distinguishing indolent from aggressive prostate cancer
A critical need in understanding the biology of prostate cancer is characterizing the
molecular differences between indolent and aggressive cases. Because DNA methylation …
molecular differences between indolent and aggressive cases. Because DNA methylation …
Detection of fusion gene transcripts in the blood samples of prostate cancer patients
Prostate cancer remains one of the most lethal cancers for men in the United States. The
study aims to detect fusion transcripts in the blood samples of prostate cancer patients. We …
study aims to detect fusion transcripts in the blood samples of prostate cancer patients. We …
Analysis of microarray data on gene expression and methylation to identify long non-coding RNAs in non-small cell lung cancer
N Feng, T Ching, Y Wang, B Liu, H Lin, O Shi… - Scientific reports, 2016 - nature.com
To identify what long non-coding RNAs (lncRNAs) are involved in non-small cell lung cancer
(NSCLC), we analyzed microarray data on gene expression and methylation. Gene …
(NSCLC), we analyzed microarray data on gene expression and methylation. Gene …
Fusion gene detection in prostate cancer samples enhances the prediction of prostate cancer clinical outcomes from radical prostatectomy through machine learning …
YP Yu, S Liu, BG Ren, J Nelson, D Jarrard… - The American journal of …, 2023 - Elsevier
Prostate cancer remains one of the most fatal malignancies in men in the United States.
Predicting the course of prostate cancer is challenging given that only a fraction of prostate …
Predicting the course of prostate cancer is challenging given that only a fraction of prostate …