Integration of GC–MS and LC–MS for untargeted metabolomics profiling

ÖC Zeki, CC Eylem, T Reçber, S Kır… - Journal of Pharmaceutical …, 2020 - Elsevier
Recently, metabolomics analyses have become increasingly common in the general
scientific community as it is applied in several researches relating to diseases diagnosis …

[HTML][HTML] Human metabolomics: strategies to understand biology

R Ramautar, R Berger, J van der Greef… - Current opinion in …, 2013 - Elsevier
Highlights•Metabolomics provides a functional read-out of the physiological status of an
organism.•A precise (dynamic) description of the clinical phenotype is missing for complex …

Impact of anesthesia and euthanasia on metabolomics of mammalian tissues: studies in a C57BL/6J mouse model

KA Overmyer, C Thonusin, NR Qi, CF Burant… - PloS one, 2015 - journals.plos.org
A critical application of metabolomics is the evaluation of tissues, which are often the primary
sites of metabolic dysregulation in disease. Laboratory rodents have been widely used for …

Canine metabolomics advances

G Carlos, FP Dos Santos, PE Fröehlich - Metabolomics, 2020 - Springer
Introduction Canis lupus familiaris is a domestic dog and many owners consider their pets
as a family member. Medical bills with dogs are overcame only by the health care received …

A comparative evaluation of tools to predict metabolite profiles from microbiome sequencing data

X Yin, T Altman, E Rutherford, KA West, Y Wu… - Frontiers in …, 2020 - frontiersin.org
Metabolomic analyses of human gut microbiome samples can unveil the metabolic potential
of host tissues and the numerous microorganisms they support, concurrently. As such …

Technical challenges in mass spectrometry-based metabolomics

F Matsuda - Mass spectrometry, 2016 - jstage.jst.go.jp
Metabolomics is a strategy for analysis, and quantification of the complete collection of
metabolites present in biological samples. Metabolomics is an emerging area of scientific …

Retention index prediction using quantitative structure–retention relationships for improving structure identification in nontargeted metabolomics

Y Wen, RIJ Amos, M Talebi, R Szucs… - Analytical …, 2018 - ACS Publications
Structure identification in nontargeted metabolomics based on liquid-chromatography
coupled to mass spectrometry (LC-MS) remains a significant challenge. Quantitative …

Getting the right answers: understanding metabolomics challenges

S Beisken, M Eiden, RM Salek - Expert review of molecular …, 2015 - Taylor & Francis
Small molecules within biological systems provide powerful insights into the biological roles,
processes and states of organisms. Metabolomics is the study of the concentrations …

SWATH data independent acquisition mass spectrometry for screening of xenobiotics in biological fluids: Opportunities and challenges for data processing

F Klont, S Jahn, C Grivet, S König, R Bonner… - Talanta, 2020 - Elsevier
SWATH data independent acquisition (DIA) mass spectrometry (MS) has become an
established technique in MS-based 'omics' research and is increasingly used for the …

Amino acids in a targeted versus a non-targeted metabolomics LC-MS/MS assay. Are the results consistent?

J Klepacki, J Klawitter, J Klawitter, A Karimpour-Fard… - Clinical …, 2016 - Elsevier
Background The results of plasma amino acid patterns in samples from kidney transplant
patients with good and impaired renal function using a targeted LC-MS/MS amino acid …