[HTML][HTML] Toward a predictive understanding of epithelial cell death

T Cumming, R Levayer - Seminars in Cell & Developmental Biology, 2024 - Elsevier
Epithelial cell death is highly prevalent during development and tissue homeostasis. While
we have a rather good understanding of the molecular regulators of programmed cell death …

[HTML][HTML] Signaling interactions among neurons impact cell fitness and death in Alzheimer's disease

C Yeates, P Deshpande, M Kango-Singh… - Neural Regeneration …, 2023 - journals.lww.com
The pathology of Alzheimer's disease involves a long preclinical period, where the
characteristic clinical symptoms of the changes in the brain are undetectable. During the …

[HTML][HTML] The interplay between metabolites and microRNAs in aqueous humor to coordinate corneal endothelium integrity

M Ueno, K Yoshii, T Yamashita, K Sonomura… - Ophthalmology …, 2023 - Elsevier
Purpose The purpose of the study was to clarify the interplay between metabolites and
microRNAs (miRs) in the aqueous humor (AqH) of bullous keratopathy (BK) patients to …

Azot expression in the Drosophila gut modulates organismal lifespan

MM Merino - Communicative & Integrative Biology, 2023 - Taylor & Francis
ABSTRACT Cell Competition emerged in Drosophila as an unexpected phenomenon, when
confronted clones of fit vs unfit cells genetically induced. During the last decade, it has been …

Epithelial recognition and elimination against aberrant cells

S Ayukawa, N Kamoshita, T Maruyama - Seminars in immunopathology, 2024 - Springer
Epithelial cells, which are non-immune cells, not only function as a physical defence barrier
but also continuously monitor and eliminate aberrant epithelial cells in their vicinity. In other …

Scribble and E-cadherin cooperate to control symmetric daughter cell positioning by multiple mechanisms

AS Chann, Y Chen, T Kinwel… - Journal of Cell …, 2023 - journals.biologists.com
The fate of the two daughter cells is intimately connected to their positioning, which is in turn
regulated by cell junction remodelling and orientation of the mitotic spindle. How multiple …

[HTML][HTML] Cellular interplay through extracellular vesicle miR-184 alleviates corneal endothelium degeneration

T Yamashita, K Asada, M Ueno, N Hiramoto… - Ophthalmology …, 2022 - Elsevier
Objective The objective of the study was to reveal the presence of cellular interplay through
extracellular vesicle (EV) microRNAs (miRs), to dampen the vicious cycle to degenerate …

Evolution within the body: the rise and fall of somatic Darwinism in the late nineteenth century

B Swiatczak - History and Philosophy of the Life Sciences, 2023 - Springer
Originating in the work of Ernst Haeckel and Wilhelm Preyer, and advanced by a Prussian
embryologist, Wilhelm Roux, the idea of struggle for existence between body parts helped to …

Oncogenic K‐RasG12V cannot overcome proliferation failure caused by loss of Ppp6c in mouse embryonic fibroblasts

M Ito, N Tanuma, Y Kotani, K Murai, A Kondo… - FEBS Open …, 2024 - Wiley Online Library
Protein phosphatase 6 is a Ser/Thr protein phosphatase and its catalytic subunit is Ppp6c.
Ppp6c is thought to be indispensable for proper growth of normal cells. On the other hand …

[HTML][HTML] Stemming Tumoral Growth: A Matter of Grotesque Organogenesis

MM Merino, JA Garcia-Sanz - Cells, 2023 - mdpi.com
The earliest metazoans probably evolved from single-celled organisms which found the
colonial system to be a beneficial organization. Over the course of their evolution, these …