Summary 1 lntroducuon 2 Classification and physlcochemlcal properties of acridines 2 1 9-
Anunoacndme and related compounds 2 2 Proflavme and related compounds 2 3 …

There are to date about six million compounds which have been identified and catalogued.
Of these, only a small percent have ever been investigated with respect to their general …

Cancer is one of the most formidable diseases of the world. In fact, if there is any disease
which the mankind is still most afraid of it is cancer. Cancer is not one disease, but a group …

New promising unsymmetrical bisacridine derivatives (UAs), have been developed. Three
groups including 36 compounds were synthesized by the condensation of 4-nitro or 4 …

Some new 1-nitro acridine derivatives were prepared and characterized. These compounds
were screened for evaluating their antimicrobial properties against Gram+ bacteria, Gram …

Members of a novel class of anticancer compounds, exhibiting high antitumor activity, ie the
unsymmetrical bisacridines (UAs), consist of two heteroaromatic ring systems. One of the …

The synthesis of two groups (Chart 1, types A and B) of conjugates of MDP
(muramyldipeptide) and nor-MDP (normuramyldipeptide) with acridine/acridone derivatives …

To determine whether the toxic effects and changes in many cell functions caused by
antitumor 1-nitroacridines are related to their enzymatically mediated covalent interstrand …

The aim of this work was to characterize the products of metabolic activation of the antitumor
drug ledakrin (Nitracrine) in model metabolic systems, where formation of drug− DNA …

Hydroxymethylacylfulvene (HMAF, MGI 114) is a novel antitumor drug and a potent pro-
apoptotic agent that has the potential to alkylate cellular nucleophiles. The objective of these …