Akt/PKB is a key master regulator of a wide range of physiological functions including
metabolism, proliferation, survival, growth, angiogenesis and migration and invasion. The …

Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver pathologies and is
associated with obesity and the metabolic syndrome, which represents a range of fatty liver …

Cancer progression involves multiple genetic and epigenetic events, which involve gain-of-
functions of oncogenes and loss-of-functions of tumor suppressor genes. Classical tumor …

Numerous hereditary syndromes caused by mutations in multiple tumor suppressor genes
can cause cancers. Germline mutations in PTEN and p53 tumor suppressor cause Cowden …

CK2 is a multitask kinase whose role is essential for a countless number of cellular
processes, many of which are critical for blood cell development. A prevailing task for this …

Ikaros (IKZF1) is a tumor suppressor that binds DNA and regulates expression of its target
genes. The mechanism of Ikaros activity as a tumor suppressor and the regulation of Ikaros …

T-cell lymphoblastic lymphoma (T-LBL) and lymphoblastic leukemia (T-ALL) represent
malignancies that arise from the transformation of immature precursor T cells. Similarities in …

Phosphorylation regulates the conformation, stability, homo-and heterotypic protein
interactions, localization, and activity of the tumor suppressor PTEN. From a simple picture …

Adult B-cell acute lymphoblastic leukemia remains a major therapeutic challenge, requiring
a better characterization of the molecular determinants underlying disease progression and …

Memory consolidation has been suggested to be protein synthesis dependent. Previous
data indicate that BDNF-induced dendritic protein synthesis is a key event in memory …