The transition to compulsion in addiction
Compulsion is a cardinal symptom of drug addiction (severe substance use disorder).
However, compulsion is observed in only a small proportion of individuals who repeatedly …
However, compulsion is observed in only a small proportion of individuals who repeatedly …
Direct dopamine terminal regulation by local striatal microcircuitry
Regulation of axonal dopamine release by local microcircuitry is at the hub of several
biological processes that govern the timing and magnitude of signaling events in reward …
biological processes that govern the timing and magnitude of signaling events in reward …
From impulses to maladaptive actions: the insula is a neurobiological gate for the development of compulsive behavior
Impulsivity is an endophenotype of vulnerability for compulsive behaviors. However, the
neural mechanisms whereby impulsivity facilitates the development of compulsive disorders …
neural mechanisms whereby impulsivity facilitates the development of compulsive disorders …
Prefrontal cortical–striatal dopamine receptor m RNA expression predicts distinct forms of impulsivity
Variation in dopamine receptor levels has been associated with different facets of
impulsivity. To further delineate the neural substrates underlying impulsive action (inability to …
impulsivity. To further delineate the neural substrates underlying impulsive action (inability to …
Reversal of cocaine‐conditioned place preference and mesocorticolimbic Zif268 expression by social interaction in rats
Little is known how social interaction, if offered as an alternative to drug consumption, affects
neural circuits involved in drug reinforcement and substance dependence. Conditioned …
neural circuits involved in drug reinforcement and substance dependence. Conditioned …
[HTML][HTML] Drug-induced activation of dopamine D1 receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and …
FA Schroeder, KL Penta, A Matevossian… - …, 2008 - nature.com
Chromatin remodeling, including histone modification, is involved in stimulant-induced gene
expression and addiction behavior. To further explore the role of dopamine D 1 receptor …
expression and addiction behavior. To further explore the role of dopamine D 1 receptor …
[HTML][HTML] Cocaine modulation of frontostriatal expression of Zif268, D2, and 5-HT2c receptors in high and low impulsive rats
M Besson, Y Pelloux, R Dilleen… - …, 2013 - nature.com
Impulsivity shares high comorbidity with substance abuse in humans, and high impulsivity
(HI) in rats has been identified as a predictive factor for cocaine addiction-like behavior …
(HI) in rats has been identified as a predictive factor for cocaine addiction-like behavior …
GDNF—a potential target to treat addiction
S Carnicella, D Ron - Pharmacology & therapeutics, 2009 - Elsevier
The glial cell line-derived neurotrophic factor (GDNF) is a secreted protein, best known for its
role in the development of the central and peripheral nervous systems and the survival of …
role in the development of the central and peripheral nervous systems and the survival of …
Gender differences in zebrafish responses to cocaine withdrawal
MAL Patiño, L Yu, BK Yamamoto, IV Zhdanova - Physiology & behavior, 2008 - Elsevier
The acute responses to cocaine and its withdrawal contribute to cocaine dependence and
potentiate relapse, with gender being one of the genetic factors affecting the outcome. Here …
potentiate relapse, with gender being one of the genetic factors affecting the outcome. Here …
[HTML][HTML] Withdrawal from escalated cocaine self-administration impairs reversal learning by disrupting the effects of negative feedback on reward exploitation: a …
Addiction is regarded as a disorder of inflexible choice with behavior dominated by
immediate positive rewards over longer-term negative outcomes. However, the …
immediate positive rewards over longer-term negative outcomes. However, the …