Mephedrone, a popular psychostimulating substance widely used illegally in recreational
purposes, exerts in rodents that regularly and intermittently were exposed to it a sensitized …

Publisher Summary This chapter discusses the central role of the basal ganglia in the
pathophysiology of stimulant addiction. It describes drug addiction as a compulsive incentive …

Impulse control disorders (ICDs), a wide spectrum of maladaptive behaviors which includes
pathological gambling, hypersexuality and compulsive buying, have been recently …

Addiction, a disorder of maladaptive brain plasticity, is associated with changes in numerous
gene expressions. Nowadays, high-throughput sequencing data on addictive substance …

The study of drug addiction integrates a broad range of research fields including social
sciences, psychology, psychiatry, behavioural neurosciences, pharmacology or genetics …

Sleep disorders have high comorbidity with drug addiction and function as major risk factors
for developing drug addiction. Recent studies have indicated that both sleep disturbance …

Schizophrenia is thought to be caused, at least in part, by dysfunction in striatal dopamine
neurotransmission. Both clinical studies and animal research have implicated the dopamine …

Rationale Topiramate is an anticonvulsant drug which has been evaluated as a therapeutic
option for the treatment of cocaine addiction during the last decade. Objectives The purpose …

Animal models have provided valuable insights into the brain mechanisms of drug addiction,
including the elucidation of neural substrates that support the primary reinforcing effects of …

The neural and psychological mechanisms of inhibitory control processes were investigated,
focusing on the cortico-basal ganglia circuits in rats and humans. These included …