Antifolate antimalarial drugs interfere with folate metabolism, a pathway essential to malaria
parasite survival. This class of drugs includes effective causal prophylactic and therapeutic …

Chemotherapy remains the most important means of controlling malaria, one of the
deadliest infectious parasitic diseases in the world. Antimalarial antifolates have been …

New inhibitors are urgently needed to overcome the burgeoning problem of drug resistance
in the treatment of Plasmodium falciparum infection. Targeting the folate pathway has …

Antifolates, inhibitors of folate synthesis or folate conversion, are used for malaria treatment.
They are developed as synergistic combinations of inhibitors of dihydrofolate reductase …

The spread of chloroquine-resistant Plasmodium falciparum in Africa has been a strong
stimulus to the development of new antimalarial drugs. Although artemisinin and related …

The development and approval of new antimicrobials capable of being used to treat
infections caused by multidrug-resistant pathogens has not kept pace with the rapid …

In recent times, the novel concept of generating hybrid molecules by pharmacophoric
hybridisation approach is fast becoming an alternative to other existing strategies of drug …

While the folate biosynthetic pathway has provided a rich source of antibacterial,
antiprotozoal, and anticancer therapies, it has not yet been exploited to develop uniquely …

Background Malaria in pregnancy is serious, and drug resistance in Africa is spreading.
Drugs have greater risks in pregnancy and determining the safety and efficacy of drugs in …

We have analyzed the activities of the antifolates pyrimethamine (PM), chlorcycloguanil
(CCG), WR99210, trimethoprim (TMP), methotrexate (MTX), and trimetrexate (TMX) against …