Progress in 7SK ribonucleoprotein structural biology
The 7SK ribonucleoprotein (RNP) is a dynamic and multifunctional regulator of RNA
Polymerase II (RNAPII) transcription in metazoa. Comprised of the non-coding 7SK RNA …
Polymerase II (RNAPII) transcription in metazoa. Comprised of the non-coding 7SK RNA …
Impaired telomere maintenance in Alazami syndrome patients with LARP7 deficiency
Background Loss of function in genes required for telomere maintenance result in disorders
known as telomeropathies, which are characterized by a pattern of symptoms including …
known as telomeropathies, which are characterized by a pattern of symptoms including …
hLARP7 C-terminal domain contains an xRRM that binds the 3΄ hairpin of 7SK RNA
CD Eichhorn, R Chug, J Feigon - Nucleic acids research, 2016 - academic.oup.com
The 7SK small nuclear ribonucleoprotein (snRNP) sequesters and inactivates the positive
transcription elongation factor b (P-TEFb), an essential eukaryotic mRNA transcription factor …
transcription elongation factor b (P-TEFb), an essential eukaryotic mRNA transcription factor …
Adolescent co-exposure to environmental cadmium and high-fat diet induces cognitive decline via Larp7 m6A-mediated SIRT6 inhibition
J Zhang, YW Xiong, HL Zhu, LL Tan, H Zhou… - Journal of Hazardous …, 2024 - Elsevier
The effects and underlying mechanisms of adolescent exposure to combined environmental
hazards on cognitive function remain unclear. Here, using a combined exposure model, we …
hazards on cognitive function remain unclear. Here, using a combined exposure model, we …
Comparison of clinical parameters with whole exome sequencing analysis results of autosomal recessive patients; a center experience
Whole-exome sequencing (WES) is an ideal method for the diagnosis of autosomal
recessive diseases. The aim of this study was to evaluate the diagnostic power of WES in …
recessive diseases. The aim of this study was to evaluate the diagnostic power of WES in …
Noncoding RNAs in endocrine malignancy
J Kentwell, JS Gundara, SB Sidhu - The oncologist, 2014 - academic.oup.com
Only recently has it been uncovered that the mammalian transcriptome includes a large
number of noncoding RNAs (ncRNAs) that play a variety of important regulatory roles in …
number of noncoding RNAs (ncRNAs) that play a variety of important regulatory roles in …
Stabilize and connect: the role of LARP7 in nuclear non-coding RNA metabolism
La and La-related proteins (LARPs) are characterized by a common RNA interaction
platform termed the La module. This structural hallmark allows LARPs to pervade various …
platform termed the La module. This structural hallmark allows LARPs to pervade various …
Noncoding RNAs set the stage for RNA polymerase II transcription
C Studniarek, S Egloff, S Murphy - Trends in Genetics, 2021 - cell.com
Effective synthesis of mammalian messenger (m) RNAs depends on many factors that
together direct RNA polymerase II (pol II) through the different stages of the transcription …
together direct RNA polymerase II (pol II) through the different stages of the transcription …
Visualization of positive transcription elongation factor b (P-TEFb) activation in living cells
K Fujinaga, Z Luo, F Schaufele, BM Peterlin - Journal of Biological …, 2015 - ASBMB
Regulation of transcription elongation by positive transcription elongation factor b (P-TEFb)
plays a central role in determining the state of cell activation, proliferation, and …
plays a central role in determining the state of cell activation, proliferation, and …
de novo MEPCE nonsense variant associated with a neurodevelopmental disorder causes disintegration of 7SK snRNP and enhanced RNA polymerase II activation
PE Schneeberger, T Bierhals, A Neu, M Hempel… - Scientific reports, 2019 - nature.com
In eukaryotes, the elongation phase of transcription by RNA polymerase II (RNAP II) is
regulated by the transcription elongation factor b (P-TEFb), composed of Cyclin-T1 and …
regulated by the transcription elongation factor b (P-TEFb), composed of Cyclin-T1 and …