Allogeneic hematopoietic stem cell transplantation in elderly patients with acute myeloid leukemia or myelodysplastic syndromes: myth and reality

AS Del Galy, A Marouf, E Raffoux, M Robin… - Leukemia, 2021 - nature.com
Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) more frequently
affect elderly patients with a median age of 70 years and usually have a grim prognosis [1 …

[HTML][HTML] Transplantation Referral Patterns for Patients with Newly Diagnosed Higher-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia at Academic and …

B Tomlinson, M de Lima, CR Cogle… - … and cellular therapy, 2023 - Elsevier
Hematopoietic stem cell transplantation (HCT) is indicated for patients with higher-risk (HR)
myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Age, performance …

[HTML][HTML] Allotransplants for patients 65 years or older with high-risk acute myeloid leukemia

L Veltri, K Rezvani, B Oran, R Mehta, G Rondon… - Biology of Blood and …, 2019 - Elsevier
The outcome of persons> 65 years with acute myeloid leukemia (AML) is poor. A transplant
from an HLA-identical sibling or an HLA-matched unrelated donor can cure some of these …

[HTML][HTML] Allotransplantation for patients age≥ 40 years with non-Hodgkin lymphoma: encouraging progression-free survival

BL McClune, KW Ahn, HL Wang, JH Antin… - Biology of Blood and …, 2014 - Elsevier
Non-Hodgkin lymphoma (NHL) disproportionately affects older patients, who do not often
undergo allogeneic hematopoietic cell transplantation (HCT). We analyzed Center for …

Acute myeloid leukemia in the elderly: conventional and novel treatment approaches

CM Craig, GJ Schiller - Blood reviews, 2008 - Elsevier
Acute Myeloid Leukemia (AML) is a disorder affecting primarily elderly individuals and
poses significant treatment challenges. Much has been learned about the underlying …

AML in older patients: are we making progress?

E Estey - Best Practice & Research Clinical Haematology, 2009 - Elsevier
Older patients are generally, and arbitrarily, defined as those aged 60 and above. It is
important to recognise that the effect of age is modulated by numerous other prognostic …

Retrospective analysis of common scoring systems and outcome in patients older than 60 years treated with reduced-intensity conditioning regimen and alloSCT

L Castagna, S Fürst, N Marchetti, J El Cheikh… - Bone Marrow …, 2011 - nature.com
In this retrospective study, 63 patients> 60 years with hematological malignancies and
treated with allo-SCT and with reduced-intensity conditioning (RIC) were reviewed. A total of …

Real-world outcomes of unselected elderly acute myeloid leukemia patients referred to a leukemia/hematopoietic cell transplant program

SR Solomon, M Solh, KC Jackson, X Zhang… - Bone Marrow …, 2020 - nature.com
Due to perceived intolerance, many elderly AML patients do not receive therapy, and few
are considered for hematopoietic cell transplantation (HCT). To better understand “real …

Alternative novel therapies for the treatment of elderly acute myeloid leukemia patients

A Isidori, A Venditti, L Maurillo… - Expert Review of …, 2013 - Taylor & Francis
With a median age at diagnosis of approximately 65–70 years, acute myeloid leukemia
(AML) represents a major therapeutic challenge in the elderly. Only 30–35% of elderly …

Risk assessment before allogeneic hematopoietic cell transplantation for older adults with acute myeloid leukemia

ML Sorror, FR Appelbaum - Expert review of hematology, 2013 - Taylor & Francis
Acute myeloid leukemia (AML) most commonly affects patients older than 60 years.
Outcomes of treatment of older AML patients have been poor. The advent of reduced …