Assembly-line polyketide synthases (PKSs) are among the most complex protein
machineries known in nature, responsible for the biosynthesis of numerous compounds …

Microorganisms produce a wealth of structurally diverse specialized metabolites with a
remarkable range of biological activities and a wide variety of applications in medicine and …

Bacillus subtilis is widely underappreciated for its inherent biosynthetic potential. This report
comprehensively summarizes the known bioactive secondary metabolites from B. subtilis …

Covering 2000 to June 2015 This review discusses the biosynthesis of natural products that
are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes …

Marine sponges (phylum Porifera) often contain dense and diverse microbial communities,
which can constitute up to 35% of the sponge biomass. The genome of one sponge …

Microbial natural products are an invaluable source of evolved bioactive small molecules
and pharmaceutical agents. Next-generation and metagenomic sequencing indicates …

New bioinformatic tools are needed to analyze the growing volume of DNA sequence data.
This is especially true in the case of secondary metabolite biosynthesis, where the highly …

Covering: up to 2012 With the recent structural characterization of each of the component
enzymes of type I polyketide synthases, scientists are coming tantalizingly close to …

Diverse insect species harbor symbiotic bacteria, which play important roles such as
provisioning nutrients and providing defense against natural enemies [1–6]. Whereas …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …