Carboxylesterases are a multigene family of mammalian enzymes widely distributed
throughout the body that catalyze the hydrolysis of esters, amides, thioesters, and …

Rationale Psychostimulants, including methylphenidate (MPH), are the mainstay of
pharmacotherapy for attention-deficit/hyperactivity disorder (ADHD) in adults. Even though …

Clopidogrel pharmacotherapy is associated with substantial interindividual variability in
clinical response, which can translate into an increased risk of adverse outcomes …

Carboxylesterase (CES) 1 is the most abundant drug-metabolizing enzyme in human livers,
comprising approximately 1% of the entire liver proteome. CES1 is responsible for 80 …

Dabigatran etexilate (DABE) is an oral prodrug that is rapidly converted to the active
thrombin inhibitor, dabigatran (DAB), by serine esterases. The aims of the present study …

Pharmacologic and toxic effects of xenobiotics, such as drugs of abuse, depend on the
genotype and phenotype of an individual, and conversely on the isoenzymes involved in …

As the use of nanoparticles (NPs) is increasing, the potential toxicity and behavior of NPs in
living systems need to be better understood. Our goal was to evaluate the developmental …

A new ratiometric fluorescent probe derived from 2-(2-hydroxy-3-methoxyphenyl)
benzothiazole (HMBT) has been developed for selective monitoring of human …

Mammalian carboxylesterases (CES), the key members of the serine hydrolase superfamily,
hydrolyze a wide range of endogenous substances and xenobiotics bearing ester or amide …

As the most important members of serine esterase hydrolase superfamily, mammalian
carboxylesterases (CESs) are widely distributed in various tissues like liver, intestine, lung …