Drug discovery for heart failure: a new era or the end of the pipeline?
DM Kaye, H Krum - Nature reviews Drug discovery, 2007 - nature.com
Although there have been significant advances in the therapy of heart failure in recent
decades, such as the introduction of beta-blockers and antagonists of the renin–angiotensin …
decades, such as the introduction of beta-blockers and antagonists of the renin–angiotensin …
Role of sarco/endoplasmic reticulum calcium content and calcium ATPase activity in the control of cell growth and proliferation
L Lipskaia, JS Hulot, AM Lompré - Pflügers Archiv-European Journal of …, 2009 - Springer
Ca 2+, the main second messenger, is central to the regulation of cellular growth. There is
increasing evidence that cellular growth and proliferation are supported by a continuous …
increasing evidence that cellular growth and proliferation are supported by a continuous …
Reversal of cardiac dysfunction after long-term expression of SERCA2a by gene transfer in a pre-clinical model of heart failure
Y Kawase, HQ Ly, F Prunier, D Lebeche, Y Shi… - Journal of the American …, 2008 - jacc.org
Objectives: The aim of this study was to examine the effects of sarcoplasmic reticulum Ca2+
ATPase (SERCA2a) gene transfer in a swine heart failure (HF) model. Background …
ATPase (SERCA2a) gene transfer in a swine heart failure (HF) model. Background …
Newly discovered micropeptide regulators of SERCA form oligomers but bind to the pump as monomers
The recently-discovered single-span transmembrane proteins endoregulin (ELN), dwarf
open reading frame (DWORF), myoregulin (MLN), and another-regulin (ALN) are reported to …
open reading frame (DWORF), myoregulin (MLN), and another-regulin (ALN) are reported to …
Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animals
DM Kaye, A Preovolos, T Marshall, M Byrne… - Journal of the American …, 2007 - jacc.org
Objectives: The purpose of this study was to develop a clinically applicable high-efficiency
percutaneous means of therapeutic gene delivery to the failing heart. Background …
percutaneous means of therapeutic gene delivery to the failing heart. Background …
[HTML][HTML] Lentiviral vector–mediated SERCA2 gene transfer protects against heart failure and left ventricular remodeling after myocardial infarction in rats
K Niwano, M Arai, N Koitabashi, A Watanabe, Y Ikeda… - Molecular Therapy, 2008 - cell.com
Reduced expression of the SERCA2 gene impairs the calcium-handling and contractile
functions of the heart. We developed an SERCA2 gene transfer system using lentiviral …
functions of the heart. We developed an SERCA2 gene transfer system using lentiviral …
Diabetic cardiomyopathy: signaling defects and therapeutic approaches
JS Dobrin, D Lebeche - Expert review of cardiovascular therapy, 2010 - Taylor & Francis
Diabetes mellitus is the world's fastest growing disease with high morbidity and mortality
rates, predominantly as a result of heart failure. A significant number of diabetic patients …
rates, predominantly as a result of heart failure. A significant number of diabetic patients …
Sarcoplasmic reticulum Ca2+ leak in heart failure: mere observation or functional relevance?
CH George - Cardiovascular research, 2008 - academic.oup.com
Heart failure (HF) is a chronic multi-factorial disease characterized by sarcoplasmic
reticulum (SR) dysfunction that manifests as severely reduced contractility and increased …
reticulum (SR) dysfunction that manifests as severely reduced contractility and increased …
Arrhythmogenic Mutation-Linked Defects in Ryanodine Receptor Autoregulation Reveal a Novel Mechanism of Ca2+ Release Channel Dysfunction
CH George, H Jundi, N Walters, NL Thomas… - Circulation …, 2006 - Am Heart Assoc
Arrhythmogenic cardiac ryanodine receptor (RyR2) mutations are associated with stress-
induced malignant tachycardia, frequently leading to sudden cardiac death (SCD). The …
induced malignant tachycardia, frequently leading to sudden cardiac death (SCD). The …
Augmentation of left ventricular mechanics by recirculation‐mediated AAV2/1–SERCA2a gene delivery in experimental heart failure
JA Mariani, A Smolic, A Preovolos… - European journal of …, 2011 - Wiley Online Library
Aims Down‐regulation of sarcoplasmic reticulum calcium ATPase (SERCA2a) is a key
molecular abnormality in heart failure (HF), which is not currently addressed by specific …
molecular abnormality in heart failure (HF), which is not currently addressed by specific …