Worldwide distribution of cytochrome P450 alleles: a meta‐analysis of population‐scale sequencing projects
Y Zhou, M Ingelman‐Sundberg… - Clinical Pharmacology …, 2017 - Wiley Online Library
Genetic polymorphisms in cytochrome P450 (CYP) genes can result in altered metabolic
activity toward a plethora of clinically important medications. Thus, single nucleotide variants …
activity toward a plethora of clinically important medications. Thus, single nucleotide variants …
Risk factors and pathogenesis of HIV-associated neurocognitive disorder: the role of host genetics
IS Olivier, R Cacabelos, V Naidoo - International journal of molecular …, 2018 - mdpi.com
Neurocognitive impairments associated with human immunodeficiency virus (HIV) infection
remain a considerable health issue for almost half the people living with HIV, despite …
remain a considerable health issue for almost half the people living with HIV, despite …
Functioning problems associated with health conditions with greatest disease burden in South Africa: A scoping review
MY Charumbira, K Berner, QA Louw - International Journal of …, 2022 - mdpi.com
A notable rise in health-related disability for which evidence-based rehabilitation is
beneficial is evident in low-to-middle income countries. This scoping review aimed to …
beneficial is evident in low-to-middle income countries. This scoping review aimed to …
Warfarin pharmacogenomics for precision medicine in real-life clinical practice in southern Africa: Harnessing 73 variants in 29 pharmacogenes
Pharmacogenomics is universally relevant for worldwide modern therapeutics and yet
needs further development in resource-limited countries. While there is an abundance of …
needs further development in resource-limited countries. While there is an abundance of …
NeuroAIDS in children
The human immunodeficiency virus-1 (HIV-1) enters the central nervous system
compartment within the first few weeks of systemic HIV infection and may cause a spectrum …
compartment within the first few weeks of systemic HIV infection and may cause a spectrum …
Rolling out efavirenz for HIV precision medicine in Africa: are we ready for pharmacovigilance and tackling neuropsychiatric adverse effects?
C Masimirembwa, C Dandara… - Omics: a journal of …, 2016 - liebertpub.com
The introduction of antiretroviral therapy (ART) led to huge reductions in human
immunodeficiency virus (HIV)-related deaths, turning HIV-infection into a chronic condition …
immunodeficiency virus (HIV)-related deaths, turning HIV-infection into a chronic condition …
Promoting U ndetectable Equals U ntransmittable in Sub-Saharan Africa: Implication for Clinical Practice and ART Adherence
In the last decade, reliable scientific evidence has emerged to support the concept that
undetectable viral loads prevent human immunodeficiency virus (HIV). Undetectable equals …
undetectable viral loads prevent human immunodeficiency virus (HIV). Undetectable equals …
Optimizing pediatric dosing recommendations and treatment management of antiretroviral drugs using therapeutic drug monitoring data in children living with HIV
H Waalewijn, A Turkova, N Rakhmanina… - Therapeutic drug …, 2019 - journals.lww.com
Methods: A PubMed search was conducted for the literature on ARV dosing published in
English. In addition, the registration documentation of European Medicines Agency and the …
English. In addition, the registration documentation of European Medicines Agency and the …
HIV diagnostic challenges in breast-fed infants of mothers on antiretroviral therapy
R Strehlau, M Paximadis, F Patel, M Burke… - AIDS, 2019 - journals.lww.com
Background: Prompt initiation of antiretroviral therapy (ART) for HIV-infected infants is
strongly recommended but diagnostic confirmation is important as committing children to life …
strongly recommended but diagnostic confirmation is important as committing children to life …
Late-onset efavirenz toxicity: A descriptive study from Pretoria, South Africa
L Munsami, CM Schutte, M De Villiers… - Southern African Journal …, 2023 - journals.co.za
Background The neuropsychiatric side effects of efavirenz occur mainly early during
treatment and are usually mild. A lesser-known and serious complication is late-onset …
treatment and are usually mild. A lesser-known and serious complication is late-onset …