Worldwide distribution of cytochrome P450 alleles: a meta‐analysis of population‐scale sequencing projects

Y Zhou, M Ingelman‐Sundberg… - Clinical Pharmacology …, 2017 - Wiley Online Library
Genetic polymorphisms in cytochrome P450 (CYP) genes can result in altered metabolic
activity toward a plethora of clinically important medications. Thus, single nucleotide variants …

Risk factors and pathogenesis of HIV-associated neurocognitive disorder: the role of host genetics

IS Olivier, R Cacabelos, V Naidoo - International journal of molecular …, 2018 - mdpi.com
Neurocognitive impairments associated with human immunodeficiency virus (HIV) infection
remain a considerable health issue for almost half the people living with HIV, despite …

Functioning problems associated with health conditions with greatest disease burden in South Africa: A scoping review

MY Charumbira, K Berner, QA Louw - International Journal of …, 2022 - mdpi.com
A notable rise in health-related disability for which evidence-based rehabilitation is
beneficial is evident in low-to-middle income countries. This scoping review aimed to …

Warfarin pharmacogenomics for precision medicine in real-life clinical practice in southern Africa: Harnessing 73 variants in 29 pharmacogenes

S Muyambo, A Ndadza, ND Soko, B Kruger… - OMICS: A Journal of …, 2022 - liebertpub.com
Pharmacogenomics is universally relevant for worldwide modern therapeutics and yet
needs further development in resource-limited countries. While there is an abundance of …

NeuroAIDS in children

JM Wilmshurst, CK Hammond, K Donald… - Handbook of clinical …, 2018 - Elsevier
The human immunodeficiency virus-1 (HIV-1) enters the central nervous system
compartment within the first few weeks of systemic HIV infection and may cause a spectrum …

Rolling out efavirenz for HIV precision medicine in Africa: are we ready for pharmacovigilance and tackling neuropsychiatric adverse effects?

C Masimirembwa, C Dandara… - Omics: a journal of …, 2016 - liebertpub.com
The introduction of antiretroviral therapy (ART) led to huge reductions in human
immunodeficiency virus (HIV)-related deaths, turning HIV-infection into a chronic condition …

Promoting U ndetectable Equals U ntransmittable in Sub-Saharan Africa: Implication for Clinical Practice and ART Adherence

NE Thomford, D Mhandire, C Dandara… - International journal of …, 2020 - mdpi.com
In the last decade, reliable scientific evidence has emerged to support the concept that
undetectable viral loads prevent human immunodeficiency virus (HIV). Undetectable equals …

Optimizing pediatric dosing recommendations and treatment management of antiretroviral drugs using therapeutic drug monitoring data in children living with HIV

H Waalewijn, A Turkova, N Rakhmanina… - Therapeutic drug …, 2019 - journals.lww.com
Methods: A PubMed search was conducted for the literature on ARV dosing published in
English. In addition, the registration documentation of European Medicines Agency and the …

HIV diagnostic challenges in breast-fed infants of mothers on antiretroviral therapy

R Strehlau, M Paximadis, F Patel, M Burke… - AIDS, 2019 - journals.lww.com
Background: Prompt initiation of antiretroviral therapy (ART) for HIV-infected infants is
strongly recommended but diagnostic confirmation is important as committing children to life …

Late-onset efavirenz toxicity: A descriptive study from Pretoria, South Africa

L Munsami, CM Schutte, M De Villiers… - Southern African Journal …, 2023 - journals.co.za
Background The neuropsychiatric side effects of efavirenz occur mainly early during
treatment and are usually mild. A lesser-known and serious complication is late-onset …